...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Alcohol >RSV-specific anti-viral immunity is disrupted by chronic ethanol consumption
【24h】

RSV-specific anti-viral immunity is disrupted by chronic ethanol consumption

机译：RSV特异性抗病毒免疫因慢性乙醇消耗而破坏

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Alcohol-use disorders (AUD) persist in the United States and are heavily associated with an increased susceptibility to respiratory viral infections. Respiratory syncytial virus (RSV) in particular has received attention as a viral pathogen commonly detected in children and immune-compromised populations (elderly, asthmatics), yet more recently was recognized as an important viral pathogen in young adults. Our study evaluated the exacerbation of RSV-associated illness in mice that chronically consumed alcohol for 6 weeks prior to infection. Prior studies showed that lung viral titers remained elevated in these animals, leading to a hypothesis that T-cell activation and immune specificity were deficient in controlling viral spread and replication in the lungs. Herein, we confirm a reduction in RSV-specific IFN gamma production by CD8 T cells and a depolarization of Th1 (CD4+IFN gamma+) and Th2 (CD4+1-4+) T cells at day 5 after RSV infection. Furthermore, over the course of viral infection (day 1 to day 7 after RSV infection), we detected a delayed influx of neutrophils, monocytes/macrophages, and lymphocytes into the lungs. Taken together, the data show that both the early and late adaptive immunity to RSV infection are altered by chronic ethanol consumption. Future studies will determine the interactions between the innate and adaptive immune systems to delineate therapeutic targets for individuals with AUD often hospitalized by respiratory infection. (C) 2016 Elsevier Inc. All rights reserved.
机译：None

著录项

  • 来源
    《Alcohol》 |2016年第2016期|共8页
  • 作者

    Warren Kristi J.; Simet Samantha M.; Pavlik Jacqueline A.; DeVasure Jane M.; Sisson Joseph H.; Poole Jill A.; Wyatt Todd A.;

  • 作者单位

    Univ Nebraska Med Ctr Pulm Crit Care Sleep &

    Allergy Div 985910 Nebraska Med Ctr Omaha NE 68198;

    Univ Nebraska Med Ctr Pulm Crit Care Sleep &

    Allergy Div 985910 Nebraska Med Ctr Omaha NE 68198;

    Univ Nebraska Med Ctr Pulm Crit Care Sleep &

    Allergy Div 985910 Nebraska Med Ctr Omaha NE 68198;

    Univ Nebraska Med Ctr Pulm Crit Care Sleep &

    Allergy Div 985910 Nebraska Med Ctr Omaha NE 68198;

    Univ Nebraska Med Ctr Pulm Crit Care Sleep &

    Allergy Div 985910 Nebraska Med Ctr Omaha NE 68198;

    Univ Nebraska Med Ctr Pulm Crit Care Sleep &

    Allergy Div 985910 Nebraska Med Ctr Omaha NE 68198;

    Univ Nebraska Med Ctr Pulm Crit Care Sleep &

    Allergy Div 985910 Nebraska Med Ctr Omaha NE 68198;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 中毒及化学性损害;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号