Difference in sensitivities of blood HDL cholesterol and LDL cholesterol levels to alcohol in middle-aged Japanese men

Ichiro Wakabayashi

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Difference in sensitivities of blood HDL cholesterol and LDL cholesterol levels to alcohol in middle-aged Japanese men

机译：中年日男性血液HDL胆固醇和LDL胆固醇水平对酒精的敏感性差异

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摘要

Blood HDL cholesterol and LDL cholesterol levels are known to be higher and lower, respectively, in drinkers than in nondrinkers, and the beneficial effects of alcohol on cholesterol metabolism are thought to mainly explain the lower risk for ischemic heart disease in light-to-moderate drinkers than in nondrinkers. However, it remains unknown whether sensitivities of HDL and LDL cholesterol levels to alcohol are different or not. The subjects of this study were 21,572 middle-aged Japanese men, and they were divided into three tertile groups for blood HDL cholesterol levels. The relationships between habitual alcohol intake and LDL cholesterol levels were investigated in each tertile for HDL cholesterol. In all of the tertile groups for HDL cholesterol, mean LDL cholesterol levels were significantly lower in the drinking subgroups than in the nondrinking subgroup and tended to be lower with an increase of alcohol intake. In all of the tertile groups for HDL cholesterol, odds ratios for high LDL cholesterol of each drinking subgroup vs. the nondrinking subgroup were significantly lower than the reference level of 1.00, and also tended to be lower with an increase of alcohol intake. The odds ratios of each drinking subgroup tended to be lower in the 1st tertile group for HDL cholesterol than in the 3rd tertile group. Drinkers in the 1st tertile for HDL cholesterol are thought to have relatively low sensitivity of HDL cholesterol to alcohol, but clearly showed lower LDL cholesterol levels than those found in nondrinkers. Therefore, the sensitivity of LDL cholesterol level to alcohol is different from the sensitivity of HDL cholesterol level to alcohol.

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来源
《Alcohol》 |2018年第2018期|共6页
作者
Ichiro Wakabayashi;
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作者单位

Department of Environmental and Preventive Medicine Hyogo College of Medicine;

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原文格式 PDF
正文语种 eng
中图分类中毒及化学性损害;
关键词
Alcohol sensitivity; Cardiovascular disease; γ-glutamyl transpeptidase; HDL cholesterol; LDL cholesterol;

机译：酒精敏感性;心血管疾病;γ-谷氨酸转琥珀酶;HDL胆固醇;LDL胆固醇;

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2. Metrnl deficiency decreases blood HDL cholesterol and increases blood triglyceride [J] . Qi Qi, Wen-jun Hu, Si-li Zheng, 中国药理学报：英文版 . 2020,第012期
3. Difference in sensitivities of blood HDL cholesterol and LDL cholesterol levels to alcohol in middle-aged Japanese men [J] . Ichiro Wakabayashi Alcohol . 2018,第期

机译：中年日男性血液HDL胆固醇和LDL胆固醇水平对酒精的敏感性差异
4. Non-HDL Cholesterol is a More Superior Predictor of Small-Dense LDL Cholesterol than LDL Cholesterol in Japanese Subjects with TG Levels ＜400 mg/dL [J] . Kengo Moriyama, Eiko Takahashi Journal of atherosclerosis and thrombosis. . 2016,第9期

机译：非HDL胆固醇是日本受试者的小致密LDL胆固醇更优越的小致密LDL胆固醇的预测因子，TG水平<400 mg / dL
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机译：关于证实二十碳五烯酸（EPA），二十二碳六烯酸（DHA），二十二碳五烯酸（DPA）和维持正常心脏功能的健康声明的科学意见（ID 504、506、516、527、538、703、1128、1317 ，1324，1325），维持正常血糖浓度（ID 566），维持正常血压（ID 506，516，703，1317，1324），维持正常血液HDL-胆固醇浓度（ID 506），维持正常（禁食）血液中甘油三酸酯的浓度（ID 506、527、538、1317、1324、1325），维持正常血液LDL-胆固醇的浓度（ID 527、538、1317、1325、4689），保护皮肤免受光照氧化（紫外线）损伤（ID 530），EPA和DHA的吸收得到改善（ID 522，523），通过降低类花生酸，花生四烯酸衍生的介体和促红细胞生成素的水平来促进免疫系统的正常功能炎性细胞因子（ID 520、2914）和“免疫调节剂”（4690）根据1924/2006号法规（EC）第13（1）条
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7. Effect of a Coconut Oil Supplement (2g/d) on Total Cholesterol to HDL Cholesterol Ratio in Healthy Adults. [D] . Shedden, Rachel. 2017

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8. Non-HDL Cholesterol is a More Superior Predictor of Small-Dense LDL Cholesterol than LDL Cholesterol in Japanese Subjects with TG Levels 400 mg/dL [O] . Kengo Moriyama, Eiko Takahashi 2016

机译：在TG水平400 mg / dL的日本受试者中非HDL胆固醇比LDL胆固醇更能预测小密度LDL胆固醇
9. Non-HDL Cholesterol is a More Superior Predictor of Small-Dense LDL Cholesterol than LDL Cholesterol in Japanese Subjects with TG Levels ＜400 mg/dL [O] . Kengo Moriyama, Eiko Takahashi 2016

机译：非HDL胆固醇是日本受试者的小致密LDL胆固醇更优越的小致密LDL胆固醇的预测因子，TG水平<400 mg / dL
10. Comparison of Gemfibrozil and Lovastatin Therapy in Patients with High LDL andLow HDL Cholesterol Levels [R] . Barnett, M. D. 1990

机译：吉非罗齐和洛伐他汀治疗高LDL和低HDL胆固醇水平的比较

Difference in sensitivities of blood HDL cholesterol and LDL cholesterol levels to alcohol in middle-aged Japanese men

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