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首页> 外文期刊>AIDS >Virologic response of adolescents living with perinatally acquired HIV receiving antiretroviral therapy in the period of early adolescence (10-14 years) in South Africa
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Virologic response of adolescents living with perinatally acquired HIV receiving antiretroviral therapy in the period of early adolescence (10-14 years) in South Africa

机译：在南非早期青春期（10-14岁）期间占用占用HIV接受抗逆转录病毒治疗的青少年的病毒学反应

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摘要

Background and objectives: Adolescents living with perinatally acquired HIV (ALPHIV) on antiretroviral therapy (ART) have been noted to have poorer adherence, retention and virologic control compared to adolescents with non-perinatally acquired HIV, children or adults. We aimed to describe and examine factors associated with longitudinal virologic response during early adolescence. Design: A retrospective cohort study Methods: We included ALPHIV who initiated ART before age 9.5 years in South African cohorts of the International epidemiology Database to Evaluate AIDS-Southern Africa (IeDEA-SA) collaboration (2004-2016); with viral load (VL) values <400 copies/ml at age 10 years and at least one VL measurement after age 10 years. We used a log-linear quantile mixed model to assess factors associated with elevated (75th quantile) VLs. Results: We included 4396 ALPHIV, 50.7% were male, with median (interquartile range) age at ART start of 6.5 (4.5, 8.1) years. Of these, 74.9% were on a non-nucleoside reverse transcriptase inhibitor (NNRTI) at age 10 years. After adjusting for other patient characteristics, the 75th quantile VLs increased with increasing age being 3.13-fold (95% CI 2.66, 3.68) higher at age 14 versus age 10, were 3.25-fold (95% CI 2.81, 3.75) higher for patients on second-line protease-inhibitor and 1.81-fold for second-line NNRTI-based regimens (versus first-line NNRTI-based regimens). There was no difference by sex. Conclusions: As adolescents age between 10 and 14 years, they are increasingly likely to experience higher VL values, particularly if receiving second-line protease inhibitor or NNRTI-based regimens, which warrant adherence support interventions.
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  • 来源
    《AIDS》 |2021年第6期|共8页
  • 作者

    Nyakato Patience; Schomaker Michael; Sipambo Nosisa; Technau Karl-Gunter; Fatti Geoffrey; Rabie Helena; Tanser Frank; Eley Brian; Euvrard Jonathan; Wood Robin; Tsondai Priscilla R.; Yiannoutsos Constantin T.; Cornell Morna; Davies Mary-Ann;

  • 作者单位

    Univ Cape Town Fac Hlth Sci Ctr Infect Dis Epidemiol &

    Res Sch Publ Hlth &

    Family Med 5th Floor;

    Univ Cape Town Fac Hlth Sci Ctr Infect Dis Epidemiol &

    Res Sch Publ Hlth &

    Family Med 5th Floor;

    Univ Witwatersrand Chris Hani Baragwanath Acad Hosp Dept Paediat &

    Child Hlth Harriet Shezi;

    Univ Witwatersrand Rahima Moosa Mother &

    Child Hosp Fac Hlth Sci Dept Paediat &

    Child Hlth;

    Kheth Impilo AIDS Free Living Cape Town South Africa;

    Univ Stellenbosch Tygerberg Acad Hosp Dept Paediat &

    Child Hlth Stellenbosch South Africa;

    Univ KwaZulu Natal Africa Ctr Hlth &

    Populat Studies Durban South Africa;

    Univ Cape Town Red Cross War Mem Childrens Hosp Cape Town South Africa;

    Univ Cape Town Fac Hlth Sci Ctr Infect Dis Epidemiol &

    Res Sch Publ Hlth &

    Family Med 5th Floor;

    Univ Cape Town Gugulethu HIV Programme Cape Town South Africa;

    Univ Cape Town Fac Hlth Sci Ctr Infect Dis Epidemiol &

    Res Sch Publ Hlth &

    Family Med 5th Floor;

    Indiana Univ RM Fairbanks Sch Publ Hlth Dept Biostat Indianapolis IN 46204 USA;

    Univ Cape Town Fac Hlth Sci Ctr Infect Dis Epidemiol &

    Res Sch Publ Hlth &

    Family Med 5th Floor;

    Univ Cape Town Fac Hlth Sci Ctr Infect Dis Epidemiol &

    Res Sch Publ Hlth &

    Family Med 5th Floor;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 传染病;
  • 关键词

    antiretroviral therapy; early adolescence; HIV; perinatal infection; virologic response;

    机译：抗逆转录病毒治疗;早期青春期;艾滋病毒;围产期感染;病毒学反应;

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