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首页> 外文期刊>Allergy >Fish oil in infancy protects against food allergy in Iceland—Results from a birth cohort study
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Fish oil in infancy protects against food allergy in Iceland—Results from a birth cohort study

机译：婴儿期的鱼油在冰岛的食物过敏 - 来自出生队列研究的结果

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摘要

Abstract Background Consumption of oily fish or fish oil during pregnancy, lactation and infancy has been linked to a reduction in the development of allergic diseases in childhood. Methods In an observational study, Icelandic children (n = 1304) were prospectively followed from birth to 2.5 years with detailed questionnaires administered at birth and at 1 and 2 years of age, including questions about fish oil supplementation. Children with suspected food allergy were invited for physical examinations, allergic sensitization tests, and a double‐blind, placebo‐controlled food challenge if the allergy testing or clinical history indicated food allergy. The study investigated the development of sensitization to food and confirmed food allergy according to age and frequency of postnatal fish oil supplementation using proportional hazards modelling. Results The incidence of diagnosed food sensitization was significantly lower in children who received regular fish oil supplementation (relative risk: 0.51, 95% confidence interval: 0.32‐0.82). The incidence of challenge‐confirmed food allergy was also reduced, although not statistically significant (0.57, 0.30‐1.12). Children who began to receive fish oil in their first half year of life were significantly more protected than those who began later ( P = .045 for sensitization, P = .018 for allergy). Indicators of allergy severity decreased with increased fish oil consumption ( P = .013). Adjusting for parent education and allergic family history did not change the results. Conclusion Postnatal fish oil consumption is associated with decreased food sensitization and food allergies in infants and may provide an intervention strategy for allergy prevention.
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  • 来源
    《Allergy》 |2018年第6期|共8页
  • 作者

    Clausen M.; Jonasson K.; Keil T.; Beyer K.; Sigurdardottir S. T.;

  • 作者单位

    Children's HospitalLandspitali University HospitalReykjavik Iceland;

    School of Engineering and Natural SciencesUniversity of IcelandReykjavík Iceland;

    Institute of Social Medicine Epidemiology and Health EconomicsCharité ‐ Universit?tsmedizin;

    Department of Paediatric Pneumology and ImmunologyCharité ‐ Universit?tsmedizin BerlinBerlin Germany;

    Department of ImmunologyLandspitali University HospitalReykjavik Iceland;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    allergy prevention; EuroPrevall; fish oil; food allergy; infants;

    机译：过敏预防;Eureprevall;鱼油;食物过敏;婴儿;

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