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首页> 外文期刊>Allergy >Fish oil in infancy protects against food allergy in Iceland—Results from a birth cohort study
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Fish oil in infancy protects against food allergy in Iceland—Results from a birth cohort study

机译：婴儿期的鱼油在冰岛的食物过敏 - 来自出生队列研究的结果

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摘要

Abstract Background Consumption of oily fish or fish oil during pregnancy, lactation and infancy has been linked to a reduction in the development of allergic diseases in childhood. Methods In an observational study, Icelandic children (n = 1304) were prospectively followed from birth to 2.5 years with detailed questionnaires administered at birth and at 1 and 2 years of age, including questions about fish oil supplementation. Children with suspected food allergy were invited for physical examinations, allergic sensitization tests, and a double‐blind, placebo‐controlled food challenge if the allergy testing or clinical history indicated food allergy. The study investigated the development of sensitization to food and confirmed food allergy according to age and frequency of postnatal fish oil supplementation using proportional hazards modelling. Results The incidence of diagnosed food sensitization was significantly lower in children who received regular fish oil supplementation (relative risk: 0.51, 95% confidence interval: 0.32‐0.82). The incidence of challenge‐confirmed food allergy was also reduced, although not statistically significant (0.57, 0.30‐1.12). Children who began to receive fish oil in their first half year of life were significantly more protected than those who began later ( P = .045 for sensitization, P = .018 for allergy). Indicators of allergy severity decreased with increased fish oil consumption ( P = .013). Adjusting for parent education and allergic family history did not change the results. Conclusion Postnatal fish oil consumption is associated with decreased food sensitization and food allergies in infants and may provide an intervention strategy for allergy prevention.
机译：摘要在怀孕期间，哺乳期和婴儿期在怀孕期间的油鱼或鱼油的背景消耗与儿童过敏性疾病的发展有关。方法在观察研究中，冰岛儿童（N = 1304），前瞻性地随后从出生中进行了2.5岁，并在出生时给予的详细问卷和1岁，包括关于鱼油补充的问题。涉嫌食物过敏的儿童被邀请进行体检，过敏性敏化测试，以及如果过敏测试或临床历史表明食物过敏，则为双盲，安慰剂控制的食物挑战。该研究调查了使用比例危害建模的出生鱼油补充剂的年龄和频率对食品和证实食物过敏的致敏的发展。结果接受常规鱼油补充的儿童诊断良好的食物致敏发生率显着降低（相对风险：0.51,95％置信区间：0.32-0.82）。挑战证实的食物过敏的发生率也降低，虽然没有统计学意义（0.57,0.30-1.12）。在他们上半年生命的前半年开始接受鱼油的儿童受到比以后开始的人（P = .045用于敏感，P = .018用于过敏）。过敏严重程度的指标随着鱼油消耗量增加而减少（P = .013）。调整父母教育和过敏家庭历史没有改变结果。结论出生后鱼油消耗与婴儿的食物敏感和食物过敏有关，可为过敏预防提供干预策略。

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  • 来源
    《Allergy》 |2018年第6期|共8页
  • 作者

    Clausen M.; Jonasson K.; Keil T.; Beyer K.; Sigurdardottir S. T.;

  • 作者单位

    Children's HospitalLandspitali University HospitalReykjavik Iceland;

    School of Engineering and Natural SciencesUniversity of IcelandReykjavík Iceland;

    Institute of Social Medicine Epidemiology and Health EconomicsCharité ‐ Universit?tsmedizin;

    Department of Paediatric Pneumology and ImmunologyCharité ‐ Universit?tsmedizin BerlinBerlin Germany;

    Department of ImmunologyLandspitali University HospitalReykjavik Iceland;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学免疫学;
  • 关键词

    allergy prevention; EuroPrevall; fish oil; food allergy; infants;

    机译：过敏预防;Eureprevall;鱼油;食物过敏;婴儿;

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