Current perspective on eicosanoids in asthma and allergic diseases: EAACI Task Force consensus report, part I

Sokolowska Milena; Rovati G. Enrico; Diamant Zuzana; Untersmayr Eva; Schwarze Jargen; Lukasik Zuzanna; Sava Florentina; Angelina Alba; Palomares Oscar; Akdis Cezmi A.; OMahony Liam; Sanak Marek; Dahlen Sven-Erik; Woszczek Grzegorz

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Current perspective on eicosanoids in asthma and allergic diseases: EAACI Task Force consensus report, part I

机译：目前对哮喘和过敏性疾病的七碳素的透视：EACI工作组共识报告，第一部分

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Eicosanoids are biologically active lipid mediators, comprising prostaglandins, leukotrienes, thromboxanes, and lipoxins, involved in several pathophysiological processes relevant to asthma, allergies, and allied diseases. Prostaglandins and leukotrienes are the most studied eicosanoids and established inducers of airway pathophysiology including bronchoconstriction and airway inflammation. Drugs inhibiting the synthesis of lipid mediators or their effects, such as leukotriene synthesis inhibitors, leukotriene receptors antagonists, and more recently prostaglandin D-2 receptor antagonists, have been shown to modulate features of asthma and allergic diseases. This review, produced by an European Academy of Allergy and Clinical Immunology (EAACI) task force, highlights our current understanding of eicosanoid biology and its role in mediating human pathology, with a focus on new findings relevant for clinical practice, development of novel therapeutics, and future research opportunities.

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来源
《Allergy》 |2021年第1期|共17页
作者
Sokolowska Milena; Rovati G. Enrico; Diamant Zuzana; Untersmayr Eva; Schwarze Jargen; Lukasik Zuzanna; Sava Florentina; Angelina Alba; Palomares Oscar; Akdis Cezmi A.; OMahony Liam; Sanak Marek; Dahlen Sven-Erik; Woszczek Grzegorz;
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作者单位

Univ Zurich Swiss Inst Allergy &

Asthma Res Davos Switzerland;

Univ Milan Dept Pharmaceut Sci Milan Italy;

Skane Univ Hosp Dept Resp Med &

Allergol Lund Sweden;

Med Univ Vienna Ctr Pathophysiol Infectiol &

Immunol Inst Pathophysiol &

Allergy Res Vienna;

Univ Edinburgh Child Life &

Hlth Edinburgh Midlothian Scotland;

Univ Zurich Swiss Inst Allergy &

Asthma Res Davos Switzerland;

NHS Fdn Trust London North Genom Lab Hub Great Ormond St Hosp Children London England;

Univ Complutense Madrid Sch Chem Dept Biochem &

Mol Biol Madrid Spain;

Univ Complutense Madrid Sch Chem Dept Biochem &

Mol Biol Madrid Spain;

Univ Zurich Swiss Inst Allergy &

Asthma Res Davos Switzerland;

Univ Coll Cork Dept Med APC Microbiome Ireland Cork Ireland;

Jagiellonian Univ Dept Med Med Coll Krakow Poland;

Karolinska Inst Inst Environm Med Stockholm Sweden;

Kings Coll London MRC Asthma UK Ctr Allerg Mech Asthma Sch Immunol &

Microbial Sci London;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
asthma; food allergy; inflammation; leukotrienes; lipid mediators; prostaglandins; rhinitis;

机译：哮喘;食物过敏;炎症;白三烯;脂质介质;前列腺素;鼻炎;

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Current perspective on eicosanoids in asthma and allergic diseases: EAACI Task Force consensus report, part I

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