MicroRNA-Responsive DNA-Programmed Nanomedicine with Controllability of Cascaded Events for Cancer Therapy Enhancement

Qin Yi; Peng Weipan; Gong Xiaoqun; Zhou Dianming; Li Wenna; Chen Minghui; Lian Guowei; Chang Jin; Wang Tao

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MicroRNA-Responsive DNA-Programmed Nanomedicine with Controllability of Cascaded Events for Cancer Therapy Enhancement

机译：MicroRNA响应性DNA编程的纳米胺，具有级联事件的可控性癌症治疗增强

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Chemotherapy is a prime tool for cancer clinical therapy. The effectiveness has been improved considerably with the assistance of nanotechnology. However, it still meets the challenge of unsatisfied therapeutic effects caused by multidrug resistance and uncontrollable drug release. For further enhancement of the treatment performance, we develop a kind of microRNA-responsive nanomedicine that uses the biomarker microRNA-21 as a trigger of cascaded killing effects on cancer cells, including chemotherapy and gene silencing. The nanomedicine consists of a gold nanoparticle core and a DNA layer. Strand migrations within the layer can accurately control the events of anticancer drug doxorubicin release and multidrug-resistant-associated protein 1 down-regulation, yielding an alleviation of multidrug resistance and enhanced killing on cancer cells. This work demonstrates a microRNA-responsive nanomedicine in combination with chemotherapy and gene silencing, which paves the way to the advancement of DNA-based nanomedicine for cancer theranostics.

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《ACS Macro Letters》 |2021年第6期|共8页
作者
Qin Yi; Peng Weipan; Gong Xiaoqun; Zhou Dianming; Li Wenna; Chen Minghui; Lian Guowei; Chang Jin; Wang Tao;
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Sch Life Sci Tianjin 300072 Peoples R China;

Sch Life Sci Tianjin 300072 Peoples R China;

Sch Life Sci Tianjin 300072 Peoples R China;

Tianjin Ctr Dis Control &

Prevent Dept Toxicol Tianjin 300011 Peoples R China;

Sch Life Sci Tianjin 300072 Peoples R China;

Sch Life Sci Tianjin 300072 Peoples R China;

Sch Life Sci Tianjin 300072 Peoples R China;

Sch Life Sci Tianjin 300072 Peoples R China;

Sch Life Sci Tianjin 300072 Peoples R China;

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正文语种 eng
中图分类有机化学;
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MicroRNA-Responsive DNA-Programmed Nanomedicine with Controllability of Cascaded Events for Cancer Therapy Enhancement

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