On-Demand Regulation of Dual Thermosensitive Protein Hydrogels

Song Wen-Wen; Qian Zhi-Gang; Liu Hao; Chen Hai-Feng; Kaplan David L.; Xia Xiao-Xia

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On-Demand Regulation of Dual Thermosensitive Protein Hydrogels

机译：双重热敏蛋白水凝胶的按需调节

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Despite considerable progress having been made in thermosensitive protein hydrogels, regulating their thermal transitions remains a challenge due to the intricate molecular structures and interactions of the underlying protein polymers. Here we report a genetic fusion strategy to tune the unique dual thermal transitions of the C-terminal domain (CTD) of spider major ampullate spidroin 1, and explore the regulation mechanism by biophysical characterization and molecular dynamics simulations. We found that the fusion of elastin-like polypeptides (ELPs) tuned the dual transition temperatures of CTD to a physiologically relevant window, by introducing extra hydrogen bonding at low temperatures and hydrophobic interactions at high temperatures. The resulting hydrogels constructed from the fusion proteins were demonstrated to be a promising vehicle for cell preservation and delivery. This study provides insights on the regulation of the dual thermosensitive protein hydrogels and suggests a potential application of the hydrogels for consolidated cell storage and delivery.

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《ACS Macro Letters》 |2021年第4期|共6页
作者
Song Wen-Wen; Qian Zhi-Gang; Liu Hao; Chen Hai-Feng; Kaplan David L.; Xia Xiao-Xia;
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作者单位

Shanghai Jiao Tong Univ Sch Life Sci &

Biotechnol State Key Lab Microbial Metab Joint Int Res Lab Metab &

Dev Sci Shanghai 200240 Peoples R China;

Shanghai Jiao Tong Univ Sch Life Sci &

Biotechnol State Key Lab Microbial Metab Joint Int Res Lab Metab &

Dev Sci Shanghai 200240 Peoples R China;

Shanghai Jiao Tong Univ Sch Life Sci &

Biotechnol State Key Lab Microbial Metab Joint Int Res Lab Metab &

Dev Sci Shanghai 200240 Peoples R China;

Shanghai Jiao Tong Univ Sch Life Sci &

Biotechnol State Key Lab Microbial Metab Joint Int Res Lab Metab &

Dev Sci Shanghai 200240 Peoples R China;

Tufts Univ Dept Biomed Engn Medford MA 02155 USA;

Shanghai Jiao Tong Univ Sch Life Sci &

Biotechnol State Key Lab Microbial Metab Joint Int Res Lab Metab &

Dev Sci Shanghai 200240 Peoples R China;

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正文语种 eng
中图分类有机化学;
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机译：热休克蛋白在棉花耐热和热敏系中的表达

On-Demand Regulation of Dual Thermosensitive Protein Hydrogels

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