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首页> 外文期刊>Analytical and bioanalytical chemistry >Determination of n-octanol-water partition coefficients by hollow-fiber membrane solvent microextraction coupled with HPLC
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Determination of n-octanol-water partition coefficients by hollow-fiber membrane solvent microextraction coupled with HPLC

机译：中空纤维膜溶剂微萃取-HPLC法测定正辛醇-水分配系数

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摘要

A novel direct method has been developed for determination of n-octanol-water partition coefficients by hollow-fiber membrane solvent microextraction (HFMSME) combined with high-performance liquid chromatography (HPLC). The compound of interest is dissolved in water with sonication and a hollow fiber containing octanol inside is placed in the sample solution to perform microextraction. After microextraction the concentrations in both the aqueous and n-octanol phases are analyzed by HPLC with UV detection. The method was evaluated with ten reference compounds and shown to be suitable for determination of the partition coefficients of organic compounds accurately, cheaply, simply, and quickly. Previously unknown n-octanol-water partition coefficients have been obtained for other compounds by use of the hollow-fiber membrane solvent-microextraction technique.
机译：通过中空纤维膜溶剂微萃取（HFMSME）结合高效液相色谱（HPLC），开发了一种直接测定辛醇-水分配系数的新方法。将感兴趣的化合物通过超声处理溶解在水中，并将内部含有辛醇的中空纤维置于样品溶液中以进行微萃取。微萃取后，通过具有UV检测的HPLC分析水相和正辛醇相中的浓度。用十种参考化合物对该方法进行了评估，结果表明该方法适用于准确，廉价，简单，快速地测定有机化合物的分配系数。通过使用中空纤维膜溶剂-微萃取技术，已经获得了其他化合物的先前未知的正辛醇-水分配系数。

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