Expression of GSK3 beta, PICK1, NEFL, C4, NKCC1 and Synaptophysin in peripheral blood mononuclear cells of the first-episode schizophrenia patients

Zhang Tingting; Tang Yamei; Yang Xiudeng; Wang Xuyi; Ding Shan; Huang Kai; Liu Yong; Lang Bing

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Expression of GSK3 beta, PICK1, NEFL, C4, NKCC1 and Synaptophysin in peripheral blood mononuclear cells of the first-episode schizophrenia patients

机译：GSK3β，PICK1，NEFL，C4，NKCC1和突出素在第一集中精神分裂症患者的外周血单核细胞中的表达

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Schizophrenia (SZ) is a severe neurodevelopmental disease with unknown pathogenic mechanisms characterized with impaired cognitive function. The disturbed synaptic plasticity and synaptic loss have been widely reported in SZ. In this study, 41 first-episode schizophrenia (FES) patients and 44 healthy controls (HC) were recruited and the expression of six genes commonly relevant to synaptic functions was examined in the peripheral blood mononuclear cells (PBMCs). These genes were glycogen synthase kinase 3 beta (GSK3 beta), protein interacting with C-kinase 1 (PICK1), synaptophysin (SYP), neurofilament light (NEFL), complement component 4 (C4) and Na+-K--2Cl(-) cotransporter 1 (NKCC1). Real-time quantitative polymerase chain reaction (qPCR) was performed to determine the quantity of individual mRNA template. Compared to HC, the expression of PICK1 and NKCC1 genes in FES patients was relatively lower whereas the expression of NEFL was higher. No difference for the mRNA expression of GSK3 beta, SYP and C4 genes was detected between FES patients and HC, nor was the gender difference; Interestingly, the mRNA expression of PICK1 in female FES patients was significantly decreased compared to female HC, but not in males; and the NEFL gene was up-regulated in male FES patients but not in females. Our findings support an abnormal expression profile of synapse-related genes in the PBMCs of FES patients.

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来源
《Asian journal of psychiatry》 |2021年第1期|共5页
作者
Zhang Tingting; Tang Yamei; Yang Xiudeng; Wang Xuyi; Ding Shan; Huang Kai; Liu Yong; Lang Bing;
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作者单位

Cent South Univ Xiangya Hosp 2 Dept Lab Med Changsha 410011 Hunan Peoples R China;

Cent South Univ Xiangya Hosp 2 Dept Lab Med Changsha 410011 Hunan Peoples R China;

Shaoyang Univ Affifiliated Hosp 1 Dept Lab Med Shaoyang 422001 Hunan Peoples R China;

Cent South Univ China Natl Technol Inst Mental Disorders Hunan Key Lab Psychiat &

Mental Hlth;

Cent South Univ China Natl Technol Inst Mental Disorders Hunan Key Lab Psychiat &

Mental Hlth;

Cent South Univ China Natl Technol Inst Mental Disorders Hunan Key Lab Psychiat &

Mental Hlth;

Cent South Univ China Natl Technol Inst Mental Disorders Hunan Key Lab Psychiat &

Mental Hlth;

Cent South Univ China Natl Technol Inst Mental Disorders Hunan Key Lab Psychiat &

Mental Hlth;

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原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学;
关键词
First-episode schizophrenia; GSK3 beta; PICK1; NEFL; mRNA;

机译：首发精神分裂症;GSK3 Beta;PICK1;NEFL;mRNA;

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Expression of GSK3 beta, PICK1, NEFL, C4, NKCC1 and Synaptophysin in peripheral blood mononuclear cells of the first-episode schizophrenia patients

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