Multivariate determination of ~(13)CO_2/~(12)CO_2 ratios in exhaled mouse breath with mid-infrared hollow waveguide gas sensors

Felicia Seichter; Andreas Wilk; Katharina W?rle; Seong-Soo Kim; Josef A. Vogt; Ulrich Wachter; Peter Radermacher; Boris Mizaikoff

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Multivariate determination of ~(13)CO_2/~(12)CO_2 ratios in exhaled mouse breath with mid-infrared hollow waveguide gas sensors

机译：用中红外空心波导气体传感器多变量测定呼出气中〜（13）CO_2 /〜（12）CO_2的比率

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The ~(12)CO_2/~(13)CO_2 isotope ratio is a well-known marker in breath for a variety of biochemical processes and enables monitoring, e.g., of the glucose metabolism during sepsis. Using animal models-here, at a mouse intensive care unit-the simultaneous determination of ~(12)CO_2 and ~(13)CO_2 within small volumes of mouse breath was enabled by coupling a novel low-volume hollow waveguide gas cell to a compact Fourier transform infrared spectrometer combined with multivariate data evaluation based on partial least squares regression along with optimized data preprocessing routines.

机译：〜（12）CO_2 /〜（13）CO_2同位素比是各种生化过程中呼吸中众所周知的标志物，并且能够监测例如败血症期间的葡萄糖代谢。使用动物模型-在这里，在小鼠重症监护室-通过将新型小体积空心波导气室耦合到紧凑型装置，可以在小体积的小鼠呼吸中同时测定〜（12）CO_2和〜（13）CO_2傅立叶变换红外光谱仪结合基于偏最小二乘回归的多元数据评估以及优化的数据预处理程序。

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《Analytical and bioanalytical chemistry》 |2013年第14期|共7页
作者
Felicia Seichter; Andreas Wilk; Katharina W?rle; Seong-Soo Kim; Josef A. Vogt; Ulrich Wachter; Peter Radermacher; Boris Mizaikoff;
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正文语种 eng
中图分类分析化学;
关键词
FT-IR spectroscopy; Mid-infrared gas sensor; Hollow waveguide; Mouse sepsis model; Glucose/insulin metabolism disorder; ~(13)CO_2 enrichment; TTR; Multivariate data analysis;

机译：FT-IR光谱;中红外气体传感器;空心波导;小鼠败血症模型;葡萄糖/胰岛素代谢紊乱;〜（13）CO_2富集;TTR;多元数据分析;

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1. Multivariate determination of ~(13)CO_2/~(12)CO_2 ratios in exhaled mouse breath with mid-infrared hollow waveguide gas sensors [J] . Felicia Seichter, Andreas Wilk, Katharina W?rle, Analytical and bioanalytical chemistry . 2013,第14期

机译：用中红外空心波导气体传感器多变量测定呼出气中〜（13）CO_2 /〜（12）CO_2的比率
2. Toward the quantification of the 13CO₂/12CO₂ ratio in exhaled mouse breath with mid-infrared hollow waveguide gas sensors [J] . Andreas Wilk, Felicia Seichter, Seong-Soo Kim, Analytical and Bioanalytical Chemistry . 2012,第1期

机译：量化中空空心小鼠呼出气中 13 CO _{2 / 12 CO _{2 的比例波导气体传感器}}
3. Diagnosis of small intestinal bacterial overgrowth in irritable bowel syndrome patients using high-precision stable ~(13)CO_2/~(12)CO_2 isotope ratios in exhaled breath [J] . Gourab D. Banik, Abhijit Maity, Suman Som, Journal of Analytical Atomic Spectrometry . 2014,第10期

机译：利用呼气中稳定的〜（13）CO_2 /〜（12）CO_2同位素比值诊断肠易激综合征患者小肠细菌过度生长
4. Precise ~(13)CO_2/~(12)CO_2 isotopic ratio measurements for breath diagnosis with a 2 μm diode laser [C] . Sun Mingguo, Ma Hongliang, Cao Zhensong, Optics in health care and biomedical optics VI . 2014

机译：使用2μm二极管激光器精确测量〜（13）CO_2 /〜（12）CO_2同位素比率，以进行呼吸诊断
5. Pattern recognition using multivariate exploration and processing of sensor data-application to ethanol-breath analysis. [D] . Iyer, Swetha. 2011

机译：模式识别使用多元探索和传感器数据处理，应用于乙醇呼吸分析。
6. Real-time monitoring of ozone in air using substrate-integrated hollow waveguide mid-infrared sensors [O] . João Flávio da Silveira Petruci, Paula Regina Fortes, Vjekoslav Kokoric, -1

机译：使用集成了基质的空心波导中红外传感器实时监测空气中的臭氧
7. NEW CONSTRAINT ON ESTIMATION OF THE ANTHROPOGENIC CO_2 BUDGET : RELATIONSHIP BETWEEN CONCENTRATION AND δ^<13>C OF ATMOSPHERIC CO_2 DETERMINED FROM ICE CORE ANALYSIS [O] . カトウキクオ, コマキカオリ, Kikuo KATO, 1997

机译：人工合成CO_2预算估算的新约束：冰核分析测定的大气CO_2浓度与δ^ 13 C的关系

Multivariate determination of ~(13)CO_2/~(12)CO_2 ratios in exhaled mouse breath with mid-infrared hollow waveguide gas sensors

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