...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Analytical and bioanalytical chemistry >Current status of hyphenated mass spectrometry in studies of the metabolism of drugs of abuse, including doping agents
【24h】

Current status of hyphenated mass spectrometry in studies of the metabolism of drugs of abuse, including doping agents

机译：联用质谱技术在滥用药物（包括掺杂剂）代谢研究中的现状

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This paper reviews scientific contributions on the identification and/or quantification of metabolites of drugs of abuse in in vitro assays or various body samples using hyphenated mass spectrometry. Gas chromatography-mass spectrometry (GC-MS) as well as liquid chromatography-mass spectrometry (LC-MS) approaches are considered and discussed if they have been reported in the last five years and are relevant to clinical and forensic toxicology or doping control. Workup and artifact formation are discussed, and typical examples of studies of the metabolism of designer drugs, doping agents, herbal drugs, and synthetic cannabinoids are provided. Procedures for quantifying metabolites in body samples for pharmacokinetic studies or in enzyme incubations for enzyme kinetic studies are also reviewed. In conclusion, the reviewed papers showed that both GC-MS and LC-MS still have important roles to play in research into the metabolism of drugs of abuse, including doping agents.
机译：本文回顾了在使用联苯质谱技术在体外测定或各种身体样本中鉴定和/或量化滥用药物代谢产物方面的科学贡献。如果在最近五年中已经报道了气相色谱-质谱（GC-MS）和液相色谱-质谱（LC-MS）的方法，这些方法与临床和法医毒理学或掺杂控制有关，则将予以考虑和讨论。讨论了后处理和伪影形成，并提供了有关设计药物，掺杂剂，草药和合成大麻素代谢研究的典型示例。还审查了定量分析人体样品中代谢物的方法，以进行药代动力学研究或酶温育中的酶动力学研究。总之，经过审查的论文表明，GC-MS和LC-MS仍在滥用药物（包括掺杂剂）的代谢研究中仍起着重要作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号