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Lipid Nanoparticle Production Equipment for Pharmaceutical Applications

机译：脂质纳米粒子生产设备制药应用

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Knauer, the Berlin based manufacturer of high-tech laboratory instruments mostly known for its liquid chromatography systems, also supplies production equipment for pharmaceutical lipid nanoparticles. This development was made possible by combining the company's expertise in high pressure dosing and in laboratory systems engineering. New and promising developments in medicine make pharmaceuticals and their active ingredients increasingly complex and bring new challenges. Oligonucleotides, for example, are very susceptible to degradation in the human body. LNPs have shown that they can form a stable basis for the administration of active ingredients like RNA, mRNA, siRNA, or DNA-based APIs. These types of APIs and optimisation of delivery to the target cells are a very vivid field of research. Knauer's jet mixing technology has demonstrated outstanding performance for small and large-scale pharmaceutical production of vaccine lipid nanoparticles. The equipment manufacturer supplies small desktop devices to users in research and development as well as complete LNP skids for the pharmaceutical industry. The systems for production, also called IJM skids (impingement jet mixing), are designed and optimised to meet customers' specifications and documentation requirements. System installations in clean rooms (class C) have been successfully carried out. The systems are equipped with all necessary interfaces for the integration into customer's own PLC (programmable logic controller) systems.
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