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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Association between β‐cell function estimated by HOMA HOMA ‐β and prognosis of non‐diabetic patients with ischaemic stroke
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Association between β‐cell function estimated by HOMA HOMA ‐β and prognosis of non‐diabetic patients with ischaemic stroke

机译：HOMA HOMA-β估计的β细胞功能与缺血性卒中非糖尿病患者的预后的关系

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Background and purpose Studies showed that β‐cell dysfunction is associated with increased risk of cardiovascular disease and subclinical carotid atherosclerosis. This study aimed to investigate the association between β‐cell function and prognosis of non‐diabetic patients with ischaemic stroke. Methods Ischaemic stroke patients without diabetes in the Abnormal Glucose Regulation in Patients with Acute Stroke across China registry were included in this analysis. Homeostasis assessment of β‐cell function ( HOMA ‐β) was performed and classified into four groups according to quartiles. The outcomes included stroke recurrence, poor functional outcome and all‐cause mortality. Results In a total of 1244 patients, the average age was 62.3?years; 63.1% patients were male. At 1 year, the first quartile of HOMA ‐β (54.0) was associated with increased stroke recurrence (adjusted hazard ratio 2.04, 95% confidence interval 1.32–3.17, P? = ? 0.001), poor functional outcome (adjusted odds ratio 3.04, 95% confidence interval 1.90–4.88, P? ? 0.001) and mortality (adjusted hazard ratio 4.12, 95% confidence interval 2.24?7.59, P? ? 0.001) compared with the fourth quartile of HOMA ‐β (≥166.3) after adjustment for insulin resistance and other potential covariates. The second and third quartiles of HOMA ‐β were significantly associated with an increased risk of poor functional outcome. Multivariable regression analysis with restricted cubic splines showed an L‐shaped association between HOMA ‐β and outcomes at 1?year. Conclusions Our study shows that lower HOMA ‐β level is associated with poor outcomes at 1?year in non‐diabetic patients with ischaemic stroke.
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