Emerging and state of the art hemagglutinin-targeted influenza virus inhibitors.

Zhang Qiao; Liang Taizhen; Nandakumar Kutty Selva; Liu Shuwen

首页> 外文期刊>Expert opinion on pharmacotherapy >Emerging and state of the art hemagglutinin-targeted influenza virus inhibitors.

【24h】

Emerging and state of the art hemagglutinin-targeted influenza virus inhibitors.

机译：新兴和艺术血凝素靶向流感病毒抑制剂的状态。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Introduction: Seasonal influenza vaccination, together with FDA-approved neuraminidase (NA) and polymerase acidic (PA) inhibitors, is the most effective way for prophylaxis and treatment of influenza infections. However, the low efficacy of prevailing vaccines to newly emerging influenza strains and increasing resistance to available drugs drives intense research to explore more effective inhibitors. Hemagglutinin (HA), one of the major surface proteins of influenza strains, represents an attractive therapeutic target to develop such new inhibitors.

机译：None

著录项

来源
《Expert opinion on pharmacotherapy》 |2021年第6期|共14页
作者
Zhang Qiao; Liang Taizhen; Nandakumar Kutty Selva; Liu Shuwen;
展开▼
作者单位

Southern Med Univ Sch Pharmaceut Sci Guangdong Prov Key Lab New Drug Screening Guangzhou 510515;

Southern Med Univ Sch Pharmaceut Sci Guangdong Prov Key Lab New Drug Screening Guangzhou 510515;

Southern Med Univ Sch Pharmaceut Sci Karolinska Inst United Med Inflammat Ctr Guangzhou;

Southern Med Univ Sch Pharmaceut Sci Guangdong Prov Key Lab New Drug Screening Guangzhou 510515;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Drug resistance; hemagglutinin; influenza virus; inhibitors; conserved binding pockets;

机译：耐药;血凝素;流感病毒;抑制剂;保守装订口袋;
入库时间 2022-08-20 18:08:29

相似文献

外文文献
中文文献
专利

1. Cats as a potential source of emerging influenza virus infections [J] . Taisuke, Horimoto, Fumihiro, 中国病毒学：英文版 . 2015,第003期
2. No structural change due to G228S substitution of haemagglutinin in emerging H6N1 influenza virus [J] . Beuy Joob, Viroj Wiwanitkit 亚太热带生物医学杂志（英文版） . 2014,第008期
3. No structural change due to G228S substitution of haemagglutinin in emerging H6N1 influenza virus [J] . Beuy, Joob, Viroj, 亚太热带生物医学杂志：英文版 . 2014,第008期
4. Synthesis of a Hexavalent Betulinic Acid Derivative as a Hemagglutinin-Targeted Influenza Virus Entry Inhibitor [J] . Chen Yingying, Wang Xinchen, Zhu Yinbiao, Molecular pharmaceutics . 2020,第7期

机译：作为血凝素靶向流感病毒进入抑制剂的六价桦木酸衍生物的合成
5. Investigational hemagglutinin-targeted influenza virus inhibitors [J] . Zeng Li-Yan, Yang Jie, Liu Shuwen Expert opinion on investigational drugs . 2017,第1a6期

机译：研究血凝素靶向流感病毒抑制剂
6. Carbocycles related to oseltamivir as influenza virus group-1-specific neuraminidase inhibitors. Binding to N1 enzymes in the context of virus-like particles [J] . Mohan S., McAtamney S., Haselhorst T., Journal of Medicinal Chemistry . 2010,第20期

机译：与奥司他韦有关的碳环化合物作为流感病毒第1组特异性神经氨酸酶抑制剂。在病毒样颗粒的情况下与N1酶结合
7. Why are oseltamivir and zanamivir effective against the newly emerged influenza A virus (A/H1N1)? [C] . Kunqian Yu, Caiguang Yang, Weiliang Zhu, ICMSI;International conference of molecular simulations and applied informatics technologies . 2010

机译：为什么奥司他韦和扎那米韦对新出现的甲型流感病毒（A / H1N1）有效？
8. The Role of Innate Immunity and Interferon-Inducible Genes in the Regulation of Host Defense in Re-Emerging West Nile Virus and Influenza. [D] . Sidahmed, Abubaker M. E. 2014

机译：先天免疫和干扰素诱导型基因在重新出现西尼罗河病毒和流感的宿主防御中的作用。
9. A Single Dose of an Avian H3N8 Influenza Virus Vaccine Is Highly Immunogenic and Efficacious against a Recently Emerged Seal Influenza Virus in Mice and Ferrets [O] . Mariana Baz, Myeisha Paskel, Yumiko Matsuoka, 2015

机译：一剂禽H3N8流感病毒疫苗对小鼠和雪貂中新近出现的海豹流感病毒具有很高的免疫原性和有效性。
10. Synthesis of a Hexavalent Betulinic Acid Derivative as a Hemagglutinin-Targeted Influenza Virus Entry Inhibitor [O] . Yingying Chen, Xinchen Wang, Yinbiao Zhu, 2020

机译：作为血凝素靶向流感病毒进入抑制剂的六价桦木酸衍生物的合成
11. Global Surveillance of Emerging Influenza Virus Genotypes by Mass Spectrometry [R] . Sampath, R. , Russell, K. L. , Massire, C. , 2007

机译：用质谱法对新出现的流感病毒基因型进行全球监测

Emerging and state of the art hemagglutinin-targeted influenza virus inhibitors.

摘要

著录项

相似文献

相关主题

期刊订阅