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首页> 外文期刊>Analytical cellular pathology: the journal of the European Society for Analytical Cellular Pathology >Risk biomarker assessment for breast cancer progression: Replication precision of nuclear morphometry.
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Risk biomarker assessment for breast cancer progression: Replication precision of nuclear morphometry.

机译：乳腺癌进展风险生物标志物评估：核形态学复制精度。

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摘要

Nuclear morphometry is a method for quantitative measurement of histopathologic changes in the appearance of stained cell nuclei. Numerous studies have indicated that these assessments may provide clinically relevant information related to the degree of progression and malignant potential of breast neoplasia. Nuclear features are derived from computerized analysis of digitized microscope images, and a quantitative Feulgen stain for DNA was used. Features analyzed included: (1) DNA content; (2) nuclear size and shape; and (3) texture features, describing spatial features of chromatin distribution. In this study replicated measurements are described on a series of 54 breast carcinoma specimens of differing pathologic grades. Duplicate measurements were performed using two serial sections, which were processed and analyzed separately. The value of a single feature measurement, the nuclear area profile, was shown to be the strongest indicator of progression. A quantitative nuclear grade was derived and shown to be strongly correlated with not only the pathologic nuclear grade, but also with tubule formation, mitotic grade, and with the overall histopathologic grade. Analysis of replication precision showed that the standard methods of the histopathology laboratory, if practiced in a uniform manner, are sufficient to ensure reproducibility of these assessments. We argue that nuclear morphometry provides a standardized and reproducible framework for quantitative pathologic assessments.
机译：核形态计量学是定量测量染色的细胞核外观的组织病理学变化的方法。大量研究表明，这些评估可以提供与乳腺肿瘤的进展程度和恶性程度有关的临床相关信息。核特征来自数字化显微镜图像的计算机分析，并使用了定量的Feulgen DNA染色剂。分析的特征包括：（1）DNA含量; （2）核的大小和形状; （3）纹理特征，描述染色质分布的空间特征。在这项研究中，对一系列54份不同病理学等级的乳腺癌标本进行了重复测量。使用两个连续部分进行重复测量，分别进行处理和分析。单个特征测量的值（核面积图）被证明是进展的最强指标。得出了定量的核级，并且显示出不仅与病理核级密切相关，而且还与肾小管形成，有丝分裂级以及整个组织病理学级密切相关。复制精度分析表明，如果以统一的方式进行，组织病理学实验室的标准方法足以确保这些评估的可重复性。我们认为核形态计量学为定量病理评估提供了标准化和可重现的框架。

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