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The role of circular RNAs in hematological malignancies

机译：圆形RNA在血液恶性恶性肿瘤中的作用

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摘要

Circular RNAs (circRNAs) are a class of noncoding RNAs (ncRNAs) that lack a 5' end cap or a 3' end poly-(A) tail and form a circular structure through covalent bonds. Compared to linear RNAs, circRNAs are more conservative and stable, and their distribution is spatiotemporally regulated. circRNAs, as a new type of competitive endogenous RNA (ceRNA), are involved in many disease processes and are also related to the occurrence and development of tumors. Over the past three years, the role of circRNAs in hematological malignancies has received increasing attention. Related research has shown that circRNAs may regulate the occurrence and development of hematological malignancies and contribute to drug resistance through a variety of molecular mechanisms. Therefore, to lay the foundation and point out directions for further research on circRNAs, this article systematically reviews the research progress on circRNAs in leukemia, lymphoma, and myeloma.
机译：None

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  • 来源
    《Genomics》 |2020年第6期|共9页
  • 作者

    Lin Zhi; Long Fei; Zhao Mingyi; Zhang Xueyan; Yang Minghua;

  • 作者单位

    Cent South Univ Xiangya Hosp Dept Pediat Changsha 410008 Hunan Peoples R China;

    Cent South Univ Xiangya Hosp 3 Dept Gastrointestinal Surg Changsha 410013 Hunan Peoples R China;

    Cent South Univ Xiangya Hosp 3 Dept Pediat Changsha 410013 Hunan Peoples R China;

    Cent South Univ Xiangya Hosp 3 Dept Pediat Changsha 410013 Hunan Peoples R China;

    Cent South Univ Xiangya Hosp 3 Dept Pediat Changsha 410013 Hunan Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学遗传学;
  • 关键词

    circRNAs; ceRNA; Leukemia; Lymphoma; Myeloma;

    机译：Circrnas;Cerna;白血病;淋巴瘤;骨髓瘤;

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