Trends of mutation accumulation across global SARS-CoV-2 genomes: Implications for the evolution of the novel coronavirus

Roy Chayan; Mandal Santi M.; Mondal Suresh K.; Mukherjee Shriparna; Mapder Tarunendu; Ghosh Wriddhiman; Chakraborty Ranadhir

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Trends of mutation accumulation across global SARS-CoV-2 genomes: Implications for the evolution of the novel coronavirus

机译：全球SARS-COV-2基因组突变累积趋势：对新型冠状病毒的演变的影响

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To understand SARS-CoV-2 microevolution, this study explored the genome-wide frequency, gene-wise distribution, and molecular nature of all point-mutations detected across its 71,703 RNA-genomes deposited in GISAID till 21 August 2020. Globally, nsp1/nsp2 and orf7a/orf3a were the most mutation-ridden non-structural and structural genes respectively. Phylogeny of 4618 spatiotemporally-representative genomes revealed that entities belonging to the early lineages are mostly spread over Asian countries, including India, whereas the recently-derived lineages are more globally distributed. Of the total 20,163 instances of polymorphism detected across global genomes, 12,594 and 7569 involved transitions and transversions, predominated by cytidine-to-uridine and guanosine-to-uridine conversions, respectively. Positive selection of nonsynonymous mutations (dN/dS >1) in most of the structural, but not the non-structural, genes indicated that SARS-CoV-2 has already harmonized its replication/transcription machineries with the host metabolism, while it is still redefining virulence/transmissibility strategies at the molecular level. Mechanistic bases and evolutionary/pathogenicity-related implications are discussed for the predominant mutation-types.

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来源
《Genomics》 |2020年第6期|共12页
作者
Roy Chayan; Mandal Santi M.; Mondal Suresh K.; Mukherjee Shriparna; Mapder Tarunendu; Ghosh Wriddhiman; Chakraborty Ranadhir;
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作者单位

Western Univ Hlth Sci Coll Vet Med 309 East Second St Pomona CA 91766 USA;

Indian Inst Technol Kharagpur Cent Res Facil Kharagpur 721302 W Bengal India;

Indian Inst Technol Kharagpur Cent Res Facil Kharagpur 721302 W Bengal India;

Prasannadeb Womens Coll Dept Bot Jalpaiguri W Bengal India;

Indiana Univ Sch Med Dept Med Div Clin Pharmacol Indianapolis IN 46202 USA;

Bose Inst Dept Microbiol P-1-12 CIT Scheme VII M Kolkata 700054 W Bengal India;

Univ North Bengal Dept Biotechnol Darjeeling 734013 W Bengal India;

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原文格式 PDF
正文语种 eng
中图分类医学遗传学;
关键词
SARS-CoV-2; Genome-wide mutations; Transition; Transversion; Nonsynonymous and synonymous mutations; Microevolution;

机译：SARS-COV-2;基因组 - 范围突变;过渡;横转移;非纯粹和同义突变;微观化;

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2. Deletions in the genomes of fifteen inbred mouse lines and their possible implications for fat accumulation [J] . 浙江大学学报（英文版）（B辑：生物医学和生物技术） . 2007,第011期
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4. Global Psychological Implications of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Coronavirus Disease-2019 (COVID-19). What Can Be Learned From Italy. Reflections, Perspectives, Opportunities [J] . De Giorgio Andrea Frontiers in Psychology . 2020,第2期

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10. Global Genome Question: Microbes as the Key to Understanding Evolution and Ecology [R] . 2002

机译：全球基因组问题：微生物是了解进化和生态学的关键

Trends of mutation accumulation across global SARS-CoV-2 genomes: Implications for the evolution of the novel coronavirus

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