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首页> 外文期刊>Annals of allergy, asthma, and immunology >Comparison of single 2000-microg dose treatment vs. sequential repeated-dose 500-microg treatments with nebulized budesonide in acute asthma exacerbations.
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Comparison of single 2000-microg dose treatment vs. sequential repeated-dose 500-microg treatments with nebulized budesonide in acute asthma exacerbations.

机译：雾化布地奈德单次2000微克剂量治疗与连续多次重复剂量500微克治疗在急性哮喘急性发作中的比较。

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BACKGROUND: High repeated doses of inhaled corticosteroids (ICSs) are recognized as having a more rapid improvement of outcomes than a single dose of ICS in severe acute asthma. However, to our knowledge, there has been no direct comparison of the early effects of single or repeated administration of the same total dosage of ICS in children with moderate to severe exacerbations of asthma. OBJECTIVE: To compare the efficacy of a single dose of 2000 microg of nebulized budesonide with 4 repeated doses of 500 microg of nebulized budesonide in 40 children with an acute asthma exacerbation. METHODS: Randomized, double-blind, parallel study that compared the efficacy of 2000 microg of nebulized budesonide, administered in a single dose, with repeated doses (4 doses of 500 microg each) during the first 90 minutes in 40 children (mean [SD] age, 10.7 [2.4] years) with an acute asthma exacerbation that required treatment with an oral corticosteroid. Forced expiratory volume in 1 second, asthma attack score, and oxygen saturation were evaluated at 20, 40, 60, 90, 120, 180, and 240 minutes after initial treatment. Oral corticosteroids were given to all patients at 90 minutes. RESULTS: There were no significant differences in forced expiratory volume in 1 second (P = .54) at any times between the groups. Also, asthma scores and oxygen saturation were not different in either group within 90 minutes (P = .51 and P = .64, respectively) and thereafter (P = .35 and P = .87, respectively). CONCLUSION: The use of a single dose of nebulized budesonide is as effective as repeated administration of the same total dosage during the first 90 minutes before giving oral corticosteroids in children with moderate to severe exacerbations of asthma.
机译：背景：在严重的急性哮喘中，高剂量的吸入性糖皮质激素（ICS）被认为比单剂量ICS具有更快的疗效改善。然而，据我们所知，尚无直接比较相同或总剂量相同剂量的ICS单一或重复给药对中度至重度哮喘急性发作儿童的早期疗效的比较。目的：比较单剂量2000微克布地奈德雾化剂和4次重复剂量500微克布地奈德雾化剂对40例急性哮喘加重患儿的疗效。方法：随机，双盲，平行研究比较了40例儿童在头90分钟内以单剂量和重复剂量（每4剂500微克）服用2000微克雾化布地奈德的疗效（平均[SD]年龄为10.7 [2.4]岁，患有急性哮喘发作，需要口服皮质类固醇激素治疗。初次治疗后20、40、60、90、120、180和240分钟评估1秒钟的强制呼气量，哮喘发作评分和血氧饱和度。在90分钟时给所有患者口服皮质类固醇激素。结果：两组之间的任何时间在1秒内的强制呼气量均无显着差异（P = .54）。另外，两组的哮喘评分和血氧饱和度在90分钟内（分别为P = .51和P = .64）和之后（分别为P = .35和P = .87）没有差异。结论：对于患有中度至重度哮喘发作的儿童，在口服皮质类固醇激素之前的90分钟内，单次使用雾化布地奈德的效果与重复总剂量相同。

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