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首页> 外文期刊>Food & Function >Can coconut oil and treadmill exercise during the critical period of brain development ameliorate stress-related effects on anxiety-like behavior and episodic-like memory in young rats?
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Can coconut oil and treadmill exercise during the critical period of brain development ameliorate stress-related effects on anxiety-like behavior and episodic-like memory in young rats?

机译：椰子油和跑步机在脑发育的关键时期锻炼可以改善与焦虑的行为和幼鼠的焦虑行为和象衰的记忆的焦虑的效果有关吗？

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Objective: Virgin coconut oil (CO) and treadmill exercise have been reported to improve memory performance in young rats. CO has also been associated with antistress properties in young, stressed mice. Therefore, in this study we aimed to investigate whether CO and treadmill exercise could synergistically ameliorate the effects of chronic stress on anxiety-like behavior and episodic-like memory in young rats. Methods: The rats received CO and were exercised (Ex) from the 15th to the 45th day of life. The animals were supplemented with CO mL kg(-1) day(-1)) or a vehicle (V, distilled water and 0.009% Cremophor) via oral gavage. The Ex animals were placed for 30 min day(-1) on a treadmill, with the speed gradually increasing from the first week to the last. From the 46th to the 54th postnatal day, with the exception of the 51st and the 52nd day, all rats were subjected to restraint stress. Afterwards, all rats underwent the open-field test to evaluate locomotor activity and anxiety-like behavior. To evaluate episodic-like memory, all animals underwent tests to recognize object identity and special location. Lastly, lipid profile and murinometric parameters were evaluated. Results: A two-way ANOVA test followed by a Tukey test demonstrated that the CO&Ex group explored more of the unprotected central area of the OFT (27.04 +/- 4.03 s, p & 0.01), when compared to the control group (15.36 +/- 2.54 s). CO&Ex spent more time exploring the novel location of the object (71.62 +/- 3.04%, p & 0.01), when compared to the control group (58.62 +/- 2.48%). Discussion: CO and exercise during lactation can ameliorate the effects of stress on anxiety-like behavior and episodic-like memory in young rats.
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    《Food & Function》 |2018年第3期|共8页
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  • 正文语种 eng
  • 中图分类 食品工业;
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