...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Food & Function >Amelioration effects of Cirsium japonicum var. maackii extract/fractions on amyloid beta(25-35)-induced neurotoxicity in SH-SY5Y cells and identification of the main bioactive compound
【24h】

Amelioration effects of Cirsium japonicum var. maackii extract/fractions on amyloid beta(25-35)-induced neurotoxicity in SH-SY5Y cells and identification of the main bioactive compound

机译：杂志杂志的改善效应。 在淀粉样蛋白β（25-35）上的Maackii提取物/级分 - 在SH-SY5Y细胞中诱导神经毒性，并鉴定主要生物活性化合物

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Amyloid beta (A beta) is a neurotoxic peptide, and the accumulation of A beta in the brain is the major characteristic of Alzheimer's disease (AD). Recently, the beneficial effects of Cirsium japonicum var. maackii (CJM) on brain health has attracted much attention. In the present study, we investigated the ability and protective mechanisms of CJM to attenuate neuronal toxicity caused by A beta using SH-SY5Y cells. A beta(25-35) treatment decreased cell viability, whereas CJM extract/fractions increased cell viability in A beta(25-35)-treated cells. We found that CJM treatment prevented the accumulation of reactive oxygen species observed in A beta(25-35)-treated control cells. Furthermore, A beta(25-35)-mediated production of inflammatory cytokines such as interleukin-1 beta was significantly suppressed by CJM. In addition, apoptotic factors were modulated in CJM-treated cells by downregulating B-cell lymphoma-2-associated X protein and upregulating B-cell lymphoma-2 protein expression. The assays showed that the ethyl acetate (EtOAc) fraction of CJM has greater neuroprotective bioactivities compared with the other extract/fractions. The main neuroprotective active compound from the EtOAc fraction of CJM was identified as pectolinarin using ultraperformance liquid chromatography-quadrupole time-of-flight-mass spectrometry. Collectively, this study not only describes the neuroprotective effect of CJM against A beta(25-35)via the regulation of oxidative, inflammatory, and apoptotic signaling pathways, but also provides useful information for future studies on the mechanism of novel medicinal sources based on pectolinarin isolated from CJM.
机译：None

著录项

  • 来源
    《Food & Function》 |2020年第11期|共11页
  • 作者

    Kim Min Jeong; Kim Ji-Hyun; Kim Ji Hyun; Lee Sanghyun; Cho Eun Ju;

  • 作者单位

    Pusan Natl Univ Dept Food Sci &

    Nutr Pusan 46241 South Korea;

    Pusan Natl Univ Dept Food Sci &

    Nutr Pusan 46241 South Korea;

    Pusan Natl Univ Dept Food Sci &

    Nutr Pusan 46241 South Korea;

    Chung Ang Univ Dept Plant Sci &

    Technol Anseong 17546 South Korea;

    Pusan Natl Univ Dept Food Sci &

    Nutr Pusan 46241 South Korea;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 食品工业;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号