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首页> 外文期刊>Annals of allergy, asthma, and immunology >Penicillin skin testing in pregnant women with a history of penicillin allergy and group B streptococcus colonization.
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Penicillin skin testing in pregnant women with a history of penicillin allergy and group B streptococcus colonization.

机译：有青霉素过敏史和B组链球菌定植史的孕妇青霉素皮试。

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BACKGROUND: The safety and utility of penicillin skin testing (PST) in pregnant women with a history of penicillin allergy and group B streptococcus (GBS) colonization have not been studied. OBJECTIVE: To document the safety and utility of PST in pregnant women with a history of penicillin allergy and GBS colonization. METHODS: Pregnant GBS culture-positive women with a history compatible with an IgE-mediated or unknown reaction to a penicillin-class antibiotic were recruited for PST. If PST results were negative, penicillin-class antibiotics were recommended for GBS prophylaxis. Adverse reactions associated with PST or antibiotic use from the time of PST through delivery and 6 months post partum were reported. RESULTS: In 56 enrolled patients, there were only 2 mild adverse reactions (4%) associated with PST and 3 positive PST results (5%). Of the 53 PST-negative patients, 47 (89%) received at least 1 course of penicillin. There were 2 delayed-onset rashes associated with the use of intrapartum penicillins and 1 immediate-onset rash with intrapartum vancomycin therapy in a PST-positive woman. There were 7 reactions (6%) associated with 122 antibiotic courses administered. CONCLUSIONS: Penicillin skin testing can be performed safelyin pregnant women and, if the results are negative, allows penicillins to be used safely at delivery for GBS prophylaxis.
机译：背景：尚未对青霉素过敏史和B组链球菌（GBS）定植的孕妇进行青霉素皮肤测试（PST）的安全性和实用性。目的：记录有青霉素过敏和GBS定植史的孕妇PST的安全性和实用性。方法：招募具有与IgE介导或对青霉素类抗生素反应未知的病史兼容的GBS培养阳性孕妇进行PST。如果PST结果为阴性，则建议使用青霉素类抗生素预防GBS。据报道，从PST直至分娩和产后6个月，与PST或抗生素使用相关的不良反应。结果：在56名登记患者中，仅有2例与PST相关的轻度不良反应（4％）和3例PST阳性结果（5％）。在53例PST阴性患者中，有47例（89％）接受了至少1个疗程的青霉素治疗。在PST阳性的女性中，有2例与产时使用青霉素有关的迟发性皮疹，以及1例接受万古霉素治疗的即刻发生的皮疹。总共进行了122种抗生素疗程，共发生7种反应（6％）。结论：孕妇可以安全地进行青霉素皮肤测试，如果结果为阴性，则可以在分娩时安全使用青霉素预防GBS。

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