Effects of hormone replacement therapy on left ventricular diastolic function in postmenopausal women: a systematic review and meta-analysis

Chen Jian-Shu; Mou Yu-ping; Li Cai-e; Li Yin-ning; Yu Jing

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Effects of hormone replacement therapy on left ventricular diastolic function in postmenopausal women: a systematic review and meta-analysis

机译：激素替代疗法对绝经后妇女左心室舒张功能的影响：系统审查与荟萃分析

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Background Postmenopausal women tend to experience significant changes in left ventricular diastolic function (LVDF). However, there are conflicting reports about LVDF between postmenopausal women on hormone replacement therapy (HRT) and those not on HRT. This meta-analysis is to evaluate the effects of HRT on LVDF in postmenopausal women. Methods We conducted a systemic review of randomized controlled trials published up to December 31 2019 using Embase, Pubmed, and the Cochrane library database. Results Eight studies involving 668 postmenopausal women were identified. Our analysis indicated that the ratio of the peak velocity during early filing to late filling from atrial contraction improvement in HRT group was better than that in placebo group (MD 0.20, 95%CI 0.12 to 0.28). There was a significant reduction in deceleration time and left ventricular mass index in HRT group compared with placebo group (MD -21.01, 95%CI -40.11 to -1.91 vs MD -8.26, 95%CI -14.10 to -2.42). No significant difference was observed in left ventricular end systole diameter (MD 0.80, 95%CI -0.72 to 2.31), left ventricular end diastole diameter (MD -0.07, 95%CI -1.25 to 1.10), left atrial size (MD -0.33, 95%CI -1.34 to 0.68)and the isovolumic relaxation time (MD -12.08, 95%CI -27.65 to 3.5). Conclusions Our meta-analysis illustrated that postmenopausal women seem to obtain more beneficial effects from HRT on LVDF, though future studies are required to elucidate the specific mechanisms for this phenomenon.

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《Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology》 |2021年第6期|共7页
作者
Chen Jian-Shu; Mou Yu-ping; Li Cai-e; Li Yin-ning; Yu Jing;
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作者单位

Lanzhou Univ Coll Clin Med 2 Lanzhou Peoples R China;

Lanzhou Univ Coll Clin Med 2 Lanzhou Peoples R China;

Lanzhou Univ Coll Clin Med 2 Lanzhou Peoples R China;

Lanzhou Univ Coll Clin Med 2 Lanzhou Peoples R China;

Lanzhou Univ Coll Clin Med 2 Lanzhou Peoples R China;

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正文语种 eng
中图分类妇产科学;
关键词
Postmenopausal women; hormone replacement therapy; diastolic function; meta-analysis;

机译：绝经后妇女;激素替代疗法;舒张功能;META分析;

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机译：新和常规激素替代疗法对健康绝经后妇女左心室舒张功能的影响比较：多普勒和超声背散射研究
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Effects of hormone replacement therapy on left ventricular diastolic function in postmenopausal women: a systematic review and meta-analysis

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