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首页> 外文期刊>Annals of anatomy =: Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft >Neuron-specific Hu proteins sub-cellular localization in primary sensory neurons.
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Neuron-specific Hu proteins sub-cellular localization in primary sensory neurons.

机译:神经元特异性Hu蛋白在主要感觉神经元中的亚细胞定位。

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摘要

The Hu family of RNA-binding proteins is involved in many post-transcriptional mechanisms for the development and maintenance of the nervous system. Three members of the Hu family (HuB, HuC and HuD) are neuron-specific proteins. In this study, we present data using light and electron microscopy to show the sub-cellular localization of neuron-specific Hu proteins in rat primary sensory neurons taken from dorsal root ganglia (DRG). Using these techniques we morphologically revealed the presence of neuron-specific-Hu proteins in the nucleus and in the cytoplasm and discriminated the presence of Hu proteins within different cellular organelles, specifically mitochondria and Golgi apparatus, thus supporting previous ideas that NS-Hu proteins enable RNA interactions with sub-cellular organelles and may be involved in mRNA cellular localization.
机译:Hu家族的RNA结合蛋白参与许多转录后机制,以促进神经系统的发育和维持。 Hu家族的三个成员(HuB,HuC和HuD)是神经元特异性蛋白。在这项研究中,我们使用光镜和电子显微镜呈现数据,以显示取自背根神经节(DRG)的大鼠主要感觉神经元中神经元特异性Hu蛋白的亚细胞定位。使用这些技术,我们从形态上揭示了神经元特异性Hu蛋白在细胞核和细胞质中的存在,并区分了Hu蛋白在不同细胞器(特别是线粒体和高尔基体)中的存在,从而支持了NS-Hu蛋白能够实现的先前观点RNA与亚细胞器相互作用,并可能参与mRNA细胞定位。

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