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首页> 外文期刊>Annals of anatomy =: Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft >Secondary palatal closure in rats in association with relative maternofetal levels of folic acid, vitamin B12, and homocysteine.
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Secondary palatal closure in rats in association with relative maternofetal levels of folic acid, vitamin B12, and homocysteine.

机译:大鼠继发lat闭合与叶酸,维生素B12和同型半胱氨酸的相对胎儿水平相关。

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摘要

Animal experiments are used in embryological and teratological studies of matters relevant to humans. In gravid rats, a decrease in the levels of folic acid and vitamin B12 was observed in maternal blood and in amniotic fluid. At the time of secondary palatal closure (14th day of pregnancy), the folic acid level of the amniotic fluid was 73% lower than that of the maternal blood. A drop in vitamin B12 in conjunction with an increase in amniotic homocysteine levels is seen as a risk factor for malformation of the palate. The understanding of causes of cleft generation could lead to a prophylactic treatment approach.
机译:动物实验被用于与人类有关的胚胎学和畸形学研究。在妊娠大鼠中,在母血和羊水中观察到叶酸和维生素B12含量降低。在第二次pa闭合时(怀孕第14天),羊水的叶酸水平比母体血液的叶酸水平低73%。维生素B12的下降与羊膜同型半胱氨酸水平的升高相结合,被认为是上颚畸形的危险因素。对裂痕产生原因的理解可以导致预防性治疗方法。

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