Increased Twist and ZEB2 expression in a cutaneous metastasis of high-grade glioma

Masaya Nagaishi; Yoshiko Fujii; Yoshiki Sugiura; Issei Takano; Tomoji Takigawa; Hideaki Yokoo; Kensuke Suzuki

首页> 外文期刊>Neuropathology: official journal of the Japanese Society of Neuropathology >Increased Twist and ZEB2 expression in a cutaneous metastasis of high-grade glioma

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Increased Twist and ZEB2 expression in a cutaneous metastasis of high-grade glioma

机译：在高级胶质瘤的皮肤转移中增加扭曲和Zeb2表达

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Extra-central nervous system metastasis of gliomas is extremely rare, and the biological mechanism underlying it remains poorly understood. Epithelial-to-mesenchymal transition (EMT) has received attention as one of the important processes of cancer metastasis. Here we describe the case of a 32-year-old man with cutaneous metastasis of high-grade glioma, together with the analysis of EMT-related molecules. Our patient presented with a high-grade glioma in the right frontal lobe. Cutaneous metastasis under the surgical scar developed 17 months after complete resection of the intracranial tumor. Histopathology of both the original and metastatic tumors revealed hyper-cellularity; the tumors predominantly comprised glial tumor cells with poor cellular processes. Immunohisto-chemical analysis demonstrated intense expression of nt'stin, focal expression of glial fibrillary acid protein, and absence of expression of oligodendrocyte transcription factor 2, endothelial membrane antigen, or neurofilament Genetic analyses could not provide definitive diagnostic information of glioma subtypes. Immunohistochemical analysis for EMT-related biomarkers demonstrated increased Twist, zinc finger E-box-binding homeobox 2 (ZEB2), matrix metalloproteinase 2 (MMP2), and MMP9 expressions in tumor cells of the metastatic lesion compared with those of the primary lesion. Slug, E-cadherin, and N-cadherin expression were absent in both primary and metastatic lesions; however, ZEB1 expression was present in both. Our results suggest that Twist, ZEB2, MMP2, and MMP9 facilitate cutaneous metastasis of gliomas.

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来源
《Neuropathology: official journal of the Japanese Society of Neuropathology》 |2020年第2期|共6页
作者
Masaya Nagaishi; Yoshiko Fujii; Yoshiki Sugiura; Issei Takano; Tomoji Takigawa; Hideaki Yokoo; Kensuke Suzuki;
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作者单位

Department of Neurosurgery Dokkyo Medical University Saitama Medical Center Koshigaya Japan;

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原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学;
关键词
glioma; metastasis; tumor; Twist; ZEB2.;

机译：胶质瘤;转移;肿瘤;扭曲;Zeb2。;

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2. The increasing expression of GPX7 related to the malignant clinical features leading to poor prognosis of glioma patients [J] . Jiawei Yao, Shiguang Zhao, Xin Chen, 中华神经外科杂志（英文） . 2021,第002期
3. ZEB2 facilitates peritoneal metastasis by regulating the invasiveness and tumorigenesis of cancer stem-like cells in high-grade serous ovarian cancers [J] . Li Yiying, Fei He, Lin Qiwang, Oncogene . 2021,第32期

机译：Zeb2通过调节高级浆液癌癌症的癌症干细胞的侵袭性和肿瘤患者来促进腹膜转移
4. Hormone receptor status rather than HER2 status is significantly associated with increased Ki-67 and p53 expression in triple-negative breast carcinomas, and high expression of Ki-67 but not p53 is significantly associated with axillary nodal metastasis in triple-negative and high-grade non-triple-negative breast carcinomas. [J] . Han JS, Cao D, Molberg KH, American journal of clinical pathology. . 2011,第2期

机译：在三阴性乳腺癌中，激素受体状态而非HER2状态与Ki-67和p53表达增加显着相关，而在三阴性和高级别乳腺癌中，Ki-67的高表达而非p53与腋窝淋巴结转移显着相关非三阴性乳腺癌。
5. MicroRNA-200b inhibits the growth and metastasis of glioma cells via targeting ZEB2 [J] . Jian Li, Jian Yuan, Xianrui Yuan, International journal of oncology . 2021,第3期

机译：microRNA-200B通过靶向Zeb2抑制胶质瘤细胞的生长和转移
6. Increased expression of mitochondrial benzodiazepine receptors following low-level light treatment facilitates enhanced protoporphyrin Ⅸ production in glioma-derived cells in vitro [C] . S.K. Bisland, N. S. Hassanali, C. Johnson, Mechanisms for Low-Light Therapy II; Progress in Biomedical Optics and Imaging; vol.8 no.5; Proceedings of SPIE-The International Society for Optical Engineering; vol.6428 . 2007

机译：弱光处理后线粒体苯并二氮杂receptor受体的表达增加促进体外神经胶质瘤来源的细胞中原卟啉Ⅸ的产生增强
7. Convection-enhanced delivery of radiosensitizer-loaded nanoparticles for the treatment of high-grade gliomas [D] . King, Amanda Ruth 2017

机译：对流增强了放射增敏剂负载纳米颗粒的治疗，用于治疗高级神经胶质瘤
8. High Bone Sialoprotein (BSP) Expression Correlates with Increased Tumor Grade and Predicts a Poorer Prognosis of High-Grade Glioma Patients [O] . Tao Xu, Rong Qin, Jinxu Zhou, -1

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9. Hormone Receptor Status Rather Than HER2 Status Is Significantly Associated With Increased Ki-67 and p53 Expression in Triple-Negative Breast Carcinomas, and High Expression of Ki-67 but Not p53 Is Significantly Associated With Axillary Nodal Metastasis in Triple-Negative and High-Grade Non–Triple-Negative Breast Carcinomas [O] . Jeong S. Han, Dengfeng Cao, Kyle H. Molberg, 2011

机译：激素受体状态而不是HER2状态与三阴性乳腺癌中的ki-67和p53表达增加显着相关，并且Ki-67的高表达，但不是p53的三个阴性和高等级中的腋窝节点转移显着相关非三负乳腺癌
10. Control of Metastasis-Associated Gene Expression by Cell-Surface Beta-1, 6 Branched Oligosaccharide Expression. [R] . Chaney, W. G. 2002

机译：通过细胞表面β-1,6支链寡糖表达控制转移相关基因表达。

Increased Twist and ZEB2 expression in a cutaneous metastasis of high-grade glioma

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