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Upgrading the Physiological Relevance of Human Brain Organoids

机译：提升人脑器有机体的生理相关性

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摘要

The recent advent of human pluripotent stem cell (PSC)-derived 3D brain organoids has opened a window into aspects of human brain development that were not accessible before, allowing tractable monitoring and assessment of early developmental processes. However, their broad and effective use for modeling later stages of human brain development and disease is hampered by the lack of a stereotypic anatomical organization, which limits maturation processes dependent upon formation of unique cellular interactions and short- and long-range network connectivity. Emerging methods and technologies aimed at tighter regulatory control through bioengineering approaches, along with newer unbiased organoid analysis readouts, should resolve several of the current limitations. Here, we review recent advances in brain organoid generation and characterization with a focus on highlighting future directions utilizing interdisciplinary strategies that will be important for improving the physiological relevance of this model system.
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  • 来源
    《Neuron》 |2020年第6期|共15页
  • 作者

    Del Dosso Ashley; Urenda Jean-Paul; Tuan Nguyen; Quadrato Giorgia;

  • 作者单位

    Univ Southern Calif Keck Sch Med Dept Stem Cell Biol &

    Regenerat Med Los Angeles CA 90033 USA;

    Univ Southern Calif Keck Sch Med Dept Stem Cell Biol &

    Regenerat Med Los Angeles CA 90033 USA;

    Univ Southern Calif Keck Sch Med Dept Stem Cell Biol &

    Regenerat Med Los Angeles CA 90033 USA;

    Univ Southern Calif Keck Sch Med Dept Stem Cell Biol &

    Regenerat Med Los Angeles CA 90033 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
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