Transformation of Cortex-wide Emergent Properties during Motor Learning

Makino Hiroshi; Ren Chi; Liu Haixin; Kim An Na; Kondapaneni Neehar; Liu Xin; Kuzum Duygu; Komiyama Takaki

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Transformation of Cortex-wide Emergent Properties during Motor Learning

机译：电机学习期间皮质宽特性的转变

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Learning involves a transformation of brain-wide operation dynamics. However, our understanding of learning-related changes in macroscopic dynamics is limited. Here, we monitored cortex-wide activity of the mouse brain using wide-field calcium imaging while the mouse learned a motor task over weeks. Over learning, the sequential activity across cortical modules became temporally more compressed, and its trial-by-trial variability decreased. Moreover, a new flow of activity emerged during learning, originating from premotor cortex (M2), and M2 became predictive of the activity of many other modules. Inactivation experiments showed that M2 is critical for the post-learning dynamics in the cortex-wide activity. Furthermore, two-photon calcium imaging revealed that M2 ensemble activity also showed earlier activity onset and reduced variability with learning, which was accompanied by changes in the activity-movement relationship. These results reveal newly emergent properties of macroscopic cortical dynamics during motor learning and highlight the importance of M2 in controlling learned movements.

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《Neuron》 |2017年第4期|共11页
作者
Makino Hiroshi; Ren Chi; Liu Haixin; Kim An Na; Kondapaneni Neehar; Liu Xin; Kuzum Duygu; Komiyama Takaki;
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作者单位

Univ Calif San Diego Dept Neurosci Neurobiol Sect Ctr Neural Circuits &

Behav La Jolla CA;

Univ Calif San Diego Dept Neurosci Neurobiol Sect Ctr Neural Circuits &

Behav La Jolla CA;

Univ Calif San Diego Dept Neurosci Neurobiol Sect Ctr Neural Circuits &

Behav La Jolla CA;

Univ Calif San Diego Dept Neurosci Neurobiol Sect Ctr Neural Circuits &

Behav La Jolla CA;

Univ Calif San Diego Dept Neurosci Neurobiol Sect Ctr Neural Circuits &

Behav La Jolla CA;

Univ Calif San Diego Dept Elect &

Comp Engn La Jolla CA 92093 USA;

Univ Calif San Diego Dept Elect &

Comp Engn La Jolla CA 92093 USA;

Univ Calif San Diego Dept Neurosci Neurobiol Sect Ctr Neural Circuits &

Behav La Jolla CA;

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正文语种 eng
中图分类神经病学;
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1. Emergent Property in Macromolecular Motion [J] . 吴嘉麟东华大学学报（英文版） . 2003,第002期
2. Transformation of Cortex-wide Emergent Properties during Motor Learning [J] . Makino Hiroshi, Ren Chi, Liu Haixin, Neuron . 2017,第4期

机译：电机学习期间皮质宽特性的转变
3. Emergent coordination with a brain-machine interface: implications for the neural basis of motor learning [J] . Mangalam Madhur Journal of Neurophysiology . 2018,第3期

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4. Reductive and Emergent Views on Motor Learning in Rehabilitation Practice [J] . van Dijk Ludger, van der Sluis Corry, Bongers Raoul M. Journal of motor behavior . 2017,第1a6期

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6. Emergent material properties and shape transformations of fluctuating membranes with adhered proteins. [D] . Ryan, Christopher James. 2013

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7. Transformation of Cortex-wide Emergent Properties during Motor Learning [O] . Hiroshi Makino, Chi Ren, Haixin Liu, -1

机译：运动学习过程中全皮质的紧急特性的转变
8. Proximodistal Exploration in Motor Learning as an Emergent Property of Optimization [O] . Stulp, Freek, Oudeyer, Pierre-Yves 2017

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9. Toward a New Outlook on Primate Learning and Behavior: Complex Learning and Emergent Processes in Comparative Perspective [R] . Rumbaugh, D. M. , Savage-Rumbaugh, E. S. , Washburn, D. A. 1996

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Transformation of Cortex-wide Emergent Properties during Motor Learning

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