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首页> 外文期刊>Neuron >Sex-Specific Role for the Long Non-coding RNA LINC00473 in Depression
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Sex-Specific Role for the Long Non-coding RNA LINC00473 in Depression

机译:在抑郁症中长期非编码RNA LINC00473的性别特异性作用

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摘要

Depression is a common disorder that affects women at twice the rate of men. Here, we report that long non-coding RNAs (lncRNAs), a recently discovered class of regulatory transcripts, represent about one-third of the differentially expressed genes in the brains of depressed humans and display complex region- and sex-specific patterns of regulation. We identified the primate-specific, neuronal-enriched gene LINC00473 as downregulated in prefrontal cortex (PFC) of depressed females but not males. Using viral-mediated gene transfer to express LINC00473 in adult mouse PFC neurons, we mirrored the human sex-specific phenotype by inducing stress resilience solely in female mice. This sex-specific phenotype was accompanied by changes in synaptic function and gene expression selectively in female mice and, along with studies of human neuron-like cells in culture, implicates LINC00473 as a CREB effector Together, our studies identify LINC00473 as a female-specific driver of stress resilience that is aberrant in female depression.
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著录项

  • 来源
    《Neuron》 |2020年第6期|共20页
  • 作者单位

    Icahn Sch Med Mt Sinai Nash Family Dept Neurosci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Nash Family Dept Neurosci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Nash Family Dept Neurosci New York NY 10029 USA;

    Univ Pittsburgh Dept Neurosci Pittsburgh PA 15260 USA;

    Univ Texas Southwestern Med Ctr Dallas Dept Psychiat Dallas TX 75390 USA;

    Icahn Sch Med Mt Sinai Nash Family Dept Neurosci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Nash Family Dept Neurosci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Nash Family Dept Neurosci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Nash Family Dept Neurosci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Nash Family Dept Neurosci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Nash Family Dept Neurosci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Nash Family Dept Neurosci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Nash Family Dept Neurosci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Nash Family Dept Neurosci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Nash Family Dept Neurosci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Nash Family Dept Neurosci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Nash Family Dept Neurosci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Nash Family Dept Neurosci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Nash Family Dept Neurosci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Nash Family Dept Neurosci New York NY 10029 USA;

    Massachusetts Gen Hosp Gene Delivery Technol Core Cambridge MA 02139 USA;

    Univ Texas Southwestern Med Ctr Dallas Dept Psychiat Dallas TX 75390 USA;

    Icahn Sch Med Mt Sinai Nash Family Dept Neurosci New York NY 10029 USA;

    Univ Pittsburgh Dept Neurosci Pittsburgh PA 15260 USA;

    Icahn Sch Med Mt Sinai Nash Family Dept Neurosci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Nash Family Dept Neurosci New York NY 10029 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
  • 关键词

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