Differential Coding of Itch and Pain by a Subpopulation of Primary Afferent Neurons

Sharif Behrang; Ase Ariel R.; Riberiao-da-Silva Alfredo; Seguela Philippe

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Differential Coding of Itch and Pain by a Subpopulation of Primary Afferent Neurons

机译：灌胃和疼痛的差异编码通过初级传入神经元的亚群

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Itch and pain are distinct unpleasant sensations that can be triggered from the same receptive fields in the skin, raising the question of how pruriception and nociception are coded and discriminated. Here, we tested the multimodal capacity of peripheral first-order neurons, focusing on the genetically defined subpopulation of mouse C-fibers that express the chloroquine receptor MrgprA3. Using optogenetics, chemogenetics, and pharmacology, we assessed the behavioral effects of their selective stimulation in a wide variety of conditions. We show that metabotropic Gq-linked stimulation of these C-afferents, through activation of native MrgprA3 receptors or DREADDs, evokes stereotypical pruriceptive rather than nocifensive behaviors. In contrast, fast ionotropic stimulation of these same neurons through light-gated cation channels or native ATP-gated P2X3 channels predominantly evokes nocifensive rather than pruriceptive responses. We conclude that C-afferents display intrinsic multimodality, and we provide evidence that optogenetic and chemogenetic interventions on the same neuronal populations can drive distinct behavioral outputs.

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《Neuron》 |2020年第6期|共16页
作者
Sharif Behrang; Ase Ariel R.; Riberiao-da-Silva Alfredo; Seguela Philippe;
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作者单位

McGill Univ Montreal Neurol Inst Dept Neurol &

Neurosurg Montreal PQ H3A 2B4 Canada;

McGill Univ Montreal Neurol Inst Dept Neurol &

Neurosurg Montreal PQ H3A 2B4 Canada;

Alan Edwards Ctr Res Pain Montreal PQ H3A 0G1 Canada;

McGill Univ Montreal Neurol Inst Dept Neurol &

Neurosurg Montreal PQ H3A 2B4 Canada;

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正文语种 eng
中图分类神经病学;
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机译：脊髓损伤引起的C-LTmR可塑性的电生理学和行为评价：从快乐转变为疼痛传入。

Differential Coding of Itch and Pain by a Subpopulation of Primary Afferent Neurons

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