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首页> 外文期刊>Neuron >Preexisting hippocampal network dynamics constrain optogenetically induced place fields
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Preexisting hippocampal network dynamics constrain optogenetically induced place fields

机译：预先存在的海马网络动力学约束过敏诱导的地方场

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摘要

Memory models often emphasize the need to encode novel patterns of neural activity imposed by sensory drive. Prior learning and innate architecture likely restrict neural plasticity, however. Here, we test how the incorporation of synthetic hippocampal signals is constrained by preexisting circuit dynamics. We optogenetically stimulated small groups of CA1 neurons as mice traversed a chosen segment of a linear track, mimicking the emergence of place fields. Stimulation induced persistent place field remapping in stimulated and non-stimulated neurons. The emergence of place fields could be predicted from sporadic firing in the new place field location and the temporal relationship to peer neurons before the optogenetic perturbation. Circuit modification was reflected by altered spike transmission between connected pyramidal cells and inhibitory interneurons, which persisted during post-experience sleep. We hypothesize that optogenetic perturbation unmasked sub-threshold place fields. Plasticity in recurrent/lateral inhibition may drive learning through the rapid association of existing states.
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  • 来源
    《Neuron》 |2021年第6期|共23页
  • 作者

    McKenzie Sam; Huszar Roman; English Daniel F.; Kim Kanghwan; Christensen Fletcher; Yoon Euisik; Buzsaki Gyorgy;

  • 作者单位

    NYU Langone Med Ctr Dept Neurol Neurosci Inst New York NY 10016 USA;

    NYU Langone Med Ctr Dept Neurol Neurosci Inst New York NY 10016 USA;

    NYU Langone Med Ctr Dept Neurol Neurosci Inst New York NY 10016 USA;

    Univ Michigan Dept Elect Engn &

    Comp Sci Ann Arbor MI 48109 USA;

    Univ New Mexico Dept Math &

    Stat Albuquerque NM 87131 USA;

    Univ Michigan Dept Elect Engn &

    Comp Sci Ann Arbor MI 48109 USA;

    NYU Langone Med Ctr Dept Neurol Neurosci Inst New York NY 10016 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学;
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