Dopamine Oppositely Modulates State Transitions in Striosome and Matrix Direct Pathway Striatal Spiny Neurons

Prager Eric M.; Dorman Daniel B.; Hobel Zachary B.; Malgady Jeffrey M.; Blackwell Kim T.; Plotkin Joshua L.

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Dopamine Oppositely Modulates State Transitions in Striosome and Matrix Direct Pathway Striatal Spiny Neurons

机译：多巴胺对症状和基质直接途径纹状体神经元的状态转变调节状态转变

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Corticostriatal synaptic integration is partitioned among striosome (patch) and matrix compartments of the dorsal striatum, allowing compartmentalized control of discrete aspects of behavior. Despite the significance of such organization, it's unclear how compartment-specific striatal output is dynamically achieved, particularly considering new evidence that overlap of afferents is substantial. We show that dopamine oppositely shapes responses to convergent excitatory inputs in mouse striosome and matrix striatal spiny projection neurons (SPNs). Activation of postsynaptic D1 dopamine receptors promoted the generation of long-lasting synaptically evoked "up-states'' in matrix SPNs but opposed it in striosomes, which were more excitable under basal conditions. Differences in dopaminergic modulation were mediated, in part, by dendritic voltage-gated calcium channels (VGCCs): pharmacological manipulation of L-type VGCCs reversed compartment-specific responses to D1 receptor activation. These results support a novel mechanism for the selection of striatal circuit components, where fluctuating levels of dopamine shift the balance of compartment-specific striatal output.

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《Neuron》 |2020年第6期|共18页
作者
Prager Eric M.; Dorman Daniel B.; Hobel Zachary B.; Malgady Jeffrey M.; Blackwell Kim T.; Plotkin Joshua L.;
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作者单位

SUNY Stony Brook Sch Med Ctr Nervous Syst Disorders Dept Neurobiol &

Behav Stony Brook NY;

George Mason Univ Interdisciplinary Program Neurosci Fairfax VA 22030 USA;

SUNY Stony Brook Sch Med Ctr Nervous Syst Disorders Dept Neurobiol &

Behav Stony Brook NY;

SUNY Stony Brook Sch Med Ctr Nervous Syst Disorders Dept Neurobiol &

Behav Stony Brook NY;

George Mason Univ Interdisciplinary Program Neurosci Fairfax VA 22030 USA;

SUNY Stony Brook Sch Med Ctr Nervous Syst Disorders Dept Neurobiol &

Behav Stony Brook NY;

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正文语种 eng
中图分类神经病学;
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Dopamine Oppositely Modulates State Transitions in Striosome and Matrix Direct Pathway Striatal Spiny Neurons

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