Amygdala-Midbrain Connections Modulate Appetitive and Aversive Learning

Steinberg Elizabeth E.; Gore Felicity; Heifets Boris D.; Taylor Madison D.; Norville Zane C.; Beier Kevin T.; Foldy Csaba; Lerner Talia N.; Luo Liqun; Deisseroth Karl; Malenka Robert C.

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Amygdala-Midbrain Connections Modulate Appetitive and Aversive Learning

机译：Amygdala-midbrain连接调制满意和厌恶学习

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The central amygdala (CeA) orchestrates adaptive responses to emotional events. While CeA substrates for defensive behaviors have been studied extensively, CeA circuits for appetitive behaviors and their relationship to threat-responsive circuits remain poorly defined. Here, we demonstrate that the CeA sends robust inhibitory projections to the lateral substantia nigra (SNL) that contribute to appetitive and aversive learning in mice. CeA -> SNL neural responses to appetitive and aversive stimuli were modulated by expectation and magnitude consistent with a population-level salience signal, which was required for Pavlovian conditioned reward-seeking and defensive behaviors. CeA -> SNL terminal activation elicited reinforcement when linked to voluntary actions but failed to support Pavlovian associations that rely on incentive value signals. Consistent with a disinhibitory mechanism, CeA inputs preferentially target SNL GABA neurons, and CeA -> SNL and SNL dopamine neurons respond similarly to salient stimuli. Collectively, our results suggest that amygdalanigra interactions represent a previously unappreciated mechanism for influencing emotional behaviors.

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《Neuron》 |2020年第6期|共27页
作者
Steinberg Elizabeth E.; Gore Felicity; Heifets Boris D.; Taylor Madison D.; Norville Zane C.; Beier Kevin T.; Foldy Csaba; Lerner Talia N.; Luo Liqun; Deisseroth Karl; Malenka Robert C.;
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作者单位

Stanford Univ Dept Psychiat &

Behav Sci Nancy Pritzker Lab Stanford CA 94305 USA;

Stanford Univ Dept Psychiat &

Behav Sci Nancy Pritzker Lab Stanford CA 94305 USA;

Stanford Univ Dept Psychiat &

Behav Sci Nancy Pritzker Lab Stanford CA 94305 USA;

Stanford Univ Dept Psychiat &

Behav Sci Nancy Pritzker Lab Stanford CA 94305 USA;

Stanford Univ Dept Psychiat &

Behav Sci Nancy Pritzker Lab Stanford CA 94305 USA;

Stanford Univ Dept Psychiat &

Behav Sci Nancy Pritzker Lab Stanford CA 94305 USA;

Stanford Univ Dept Psychiat &

Behav Sci Nancy Pritzker Lab Stanford CA 94305 USA;

Stanford Univ Dept Bioengn Stanford CA 94305 USA;

Stanford Univ Howard Hughes Med Inst Stanford CA 94305 USA;

Stanford Univ Dept Bioengn Stanford CA 94305 USA;

Stanford Univ Dept Psychiat &

Behav Sci Nancy Pritzker Lab Stanford CA 94305 USA;

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正文语种 eng
中图分类神经病学;
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Amygdala-Midbrain Connections Modulate Appetitive and Aversive Learning

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