A Disinhibitory Circuit for Contextual Modulation in Primary Visual Cortex

Keller Andreas J.; Dipoppa Mario; Roth Morgane M.; Caudill Matthew S.; Ingrosso Alessandro; Miller Kenneth D.; Scanziani Massimo

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A Disinhibitory Circuit for Contextual Modulation in Primary Visual Cortex

机译：主视觉皮质中的语境调制中的一个不禁区电路

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Context guides perception by influencing stimulus saliency. Accordingly, in visual cortex, responses to a stimulus are modulated by context, the visual scene surrounding the stimulus. Responses are suppressed when stimulus and surround are similar but not when they differ. The underlying mechanisms remain unclear. Here, we use optical recordings, manipulations, and computational modeling to show that disinhibitory circuits consisting of vasoactive intestinal peptide (VIP)-expressing and somatostatin (SOM)-expressing inhibitory neurons modulate responses in mouse visual cortex depending on similarity between stimulus and surround, primarily by modulating recurrent excitation. When stimulus and surround are similar, VIP neurons are inactive, and activity of SOM neurons leads to suppression of excitatory neurons. However, when stimulus and surround differ, VIP neurons are active, inhibiting SOM neurons, which leads to relief of excitatory neurons from suppression. We have identified a canonical cortical disinhibitory circuit that contributes to contextual modulation and may regulate perceptual saliency.

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《Neuron》 |2020年第6期|共22页
作者
Keller Andreas J.; Dipoppa Mario; Roth Morgane M.; Caudill Matthew S.; Ingrosso Alessandro; Miller Kenneth D.; Scanziani Massimo;
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作者单位

Univ Calif San Francisco Dept Physiol San Francisco CA 94158 USA;

Columbia Univ Coll Phys &

Surg Ctr Theoret Neurosci New York NY 10027 USA;

Univ Calif San Francisco Dept Physiol San Francisco CA 94158 USA;

Univ Calif San Diego Ctr Neural Circuits &

Behav Neurobiol Sect La Jolla CA 92093 USA;

Columbia Univ Coll Phys &

Surg Ctr Theoret Neurosci New York NY 10027 USA;

Columbia Univ Coll Phys &

Surg Ctr Theoret Neurosci New York NY 10027 USA;

Univ Calif San Francisco Dept Physiol San Francisco CA 94158 USA;

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正文语种 eng
中图分类神经病学;
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5. Altered Contextual Modulation of Primary Visual Cortex Responses in Schizophrenia [J] . Kiley Seymour, Timo Stein, Lia Lira Olivier Sanders, Neuropsychopharmacology . 2013,第13期

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6. Mapping of contextual modulation in the population response of primary visual cortex [J] . David M. Alexander, Cees Van Leeuwen Cognitive Neurodynamics . 2010,第1期

机译：初级视觉皮层的人口反应中的上下文调制的映射。
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8. A MODEL OF CONTEXTUAL INTERACTIONS IN PRIMARY VISUAL CORTEX: EXAMINING THE INFLUENCE OF CORTICOGENICULATE FEEDBACK [C] . Valentin Dragoi Computational Neuroscience Conference . 1997

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9. Human neurophysiological mechanisms of contextual modulation in primary visual cortex. [D] . Schumacher, Jennifer Frances. 2010

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10. Contextual modulation of primary visual cortex by auditory signals [O] . L. S. Petro, A. T. Paton, L. Muckli 2017

机译：听觉信号对初级视觉皮层的上下文调节
11. A Disinhibitory Circuit for Contextual Modulation in Primary Visual Cortex [O] . Andreas J. Keller, Mario Dipoppa, Morgane M. Roth, 2020

机译：主视觉皮质中的上下文调制的不禁止电路
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机译：使用ps3 Cell-Be阵列的柱状主视觉皮层（V1）模型仿真

A Disinhibitory Circuit for Contextual Modulation in Primary Visual Cortex

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