Area Postrema Cell Types that Mediate Nausea-Associated Behaviors

Zhang Chuchu; Kaye Judith A.; Cai Zerong; Wang Yandan; Prescott Sara L.; Liberles Stephen D.

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Area Postrema Cell Types that Mediate Nausea-Associated Behaviors

机译：区域Postrema细胞类型，介导恶心关联行为

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Nausea, the unpleasant sensation of visceral malaise, remains a mysterious process. The area postrema is implicated in some nausea responses and is anatomically privileged to detect blood-borne signals. To investigate nausea mechanisms, we built an area postrema cell atlas through single-nucleus RNA sequencing, revealing a few neuron types. Using mouse genetic tools for cell-specific manipulation, we discovered excitatory neurons that induce nausea-related behaviors, with one neuron type mediating aversion imposed by multiple poisons. Nausea-associated responses to agonists of identified area postrema receptors were observed and suppressed by targeted cell ablation and/or gene knockout. Anatomical mapping revealed a distributed network of long-range excitatory but not inhibitory projections with subtype-specific patterning. These studies reveal the basic organization of area postrema nausea circuitry and provide a framework to

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《Neuron》 |2021年第3期|共18页
作者
Zhang Chuchu; Kaye Judith A.; Cai Zerong; Wang Yandan; Prescott Sara L.; Liberles Stephen D.;
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Harvard Med Sch Howard Hughes Med Inst Dept Cell Biol Boston MA 02115 USA;

Harvard Med Sch Howard Hughes Med Inst Dept Cell Biol Boston MA 02115 USA;

Harvard Med Sch Howard Hughes Med Inst Dept Cell Biol Boston MA 02115 USA;

Harvard Med Sch Howard Hughes Med Inst Dept Cell Biol Boston MA 02115 USA;

Harvard Med Sch Howard Hughes Med Inst Dept Cell Biol Boston MA 02115 USA;

Harvard Med Sch Howard Hughes Med Inst Dept Cell Biol Boston MA 02115 USA;

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正文语种 eng
中图分类神经病学;
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Area Postrema Cell Types that Mediate Nausea-Associated Behaviors

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