Ventral pallidum DRD3 potentiates a pallido-habenular circuit driving accumbal dopamine release and cocaine seeking

Pribiag Horia; Shin Sora; Wang Eric Hou-Jen; Sun Fangmiao; Datta Paul; Okamoto Alexander; Guss Hayden; Jain Akanksha; Wang Xiao-Yun; De Freitas Bruna; Honma Patrick; Pate Stefan; Lilascharoen Varoth; Li Yulong; Lim Byung Kook

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Ventral pallidum DRD3 potentiates a pallido-habenular circuit driving accumbal dopamine release and cocaine seeking

机译：腹侧Pallidum DRD3增强了一个苍白的Habbenular电路驱动Accumbal多巴胺释放和可卡因寻求

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Drugs of abuse induce persistent remodeling of reward circuit function, a process thought to underlie the emergence of drug craving and relapse to drug use. However, how circuit-specific, drug-induced molecular and cellular plasticity can have distributed effects on the mesolimbic dopamine reward system to facilitate relapse to drug use is not fully elucidated. Here, we demonstrate that dopamine receptor D3 (DRD3)-dependent plasticity in the ventral pallidum (VP) drives potentiation of dopamine release in the nucleus accumbens during relapse to cocaine seeking after abstinence. We show that two distinct VP DRD3(+) neuronal populations projecting to either the lateral habenula (LHb) or the ventral tegmental area (VTA) display different patterns of activity during drug seeking following abstinence from cocaine self-administration and that selective suppression of elevated activity or DRD3 signaling in the LHb-projecting population reduces drug seeking. Together, our results uncover how circuit-specific DRD3-mediated plasticity contributes to the process of drug relapse.

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《Neuron》 |2021年第13期|共29页
作者
Pribiag Horia; Shin Sora; Wang Eric Hou-Jen; Sun Fangmiao; Datta Paul; Okamoto Alexander; Guss Hayden; Jain Akanksha; Wang Xiao-Yun; De Freitas Bruna; Honma Patrick; Pate Stefan; Lilascharoen Varoth; Li Yulong; Lim Byung Kook;
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Univ Calif San Diego Div Biol Sci Neurobiol Sect La Jolla CA 92093 USA;

Univ Calif San Diego Div Biol Sci Neurobiol Sect La Jolla CA 92093 USA;

Univ Calif San Diego Div Biol Sci Neurobiol Sect La Jolla CA 92093 USA;

Peking Univ Sch Life Sci State Key Lab Membrane Biol Beijing 10087110 Peoples R China;

Univ Calif San Diego Div Biol Sci Neurobiol Sect La Jolla CA 92093 USA;

Univ Calif San Diego Div Biol Sci Neurobiol Sect La Jolla CA 92093 USA;

Univ Calif San Diego Div Biol Sci Neurobiol Sect La Jolla CA 92093 USA;

Univ Calif San Diego Div Biol Sci Neurobiol Sect La Jolla CA 92093 USA;

Univ Calif San Diego Div Biol Sci Neurobiol Sect La Jolla CA 92093 USA;

Univ Calif San Diego Div Biol Sci Neurobiol Sect La Jolla CA 92093 USA;

Univ Calif San Diego Div Biol Sci Neurobiol Sect La Jolla CA 92093 USA;

Univ Calif San Diego Div Biol Sci Neurobiol Sect La Jolla CA 92093 USA;

Univ Calif San Diego Div Biol Sci Neurobiol Sect La Jolla CA 92093 USA;

Peking Univ Sch Life Sci State Key Lab Membrane Biol Beijing 10087110 Peoples R China;

Univ Calif San Diego Div Biol Sci Neurobiol Sect La Jolla CA 92093 USA;

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正文语种 eng
中图分类神经病学;
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1. Ventral Pallidum Is the Primary Target for Accumbens D1 Projections Driving Cocaine Seeking [J] . Pardo-Garcia Thibaut R., Garcia-Keller Constanza, Penaloza Tiffany, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2019,第11期

机译：腹侧Pallidum是Accumbens D1投影的主要目标驱动可卡因寻求
2. Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking [J] . MahlerS.V., VazeyE.M., BeckleyJ.T., Nature neuroscience . 2014,第4期

机译：设计受体在可卡因寻找中显示腹侧苍白球输入腹侧被盖区的作用
3. Disulfiram stimulates dopamine release from noradrenergic terminals and potentiates cocaine-induced dopamine release in the prefrontal cortex [J] . DevotoP., FloreG., SabaP., Psychopharmacology . 2012,第4期

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4. Regulation of Dopamine Release by Striatal Acetylcholine and Nicotine Is via Distinct Nicotinic Acetylcholine Receptors in Dorsal vs. Ventral Striatum [C] . Richard Exley, Michael A. Clements, Stephanie J. Cragg Triennial Meeting of the International Basal Ganglia Society . 2009

机译：通过纹状体乙酰胆碱和尼古丁对多巴胺释放的调节是通过不同的烟碱乙酰胆碱受体在背侧与腹侧纹状体中
5. Corticotropin releasing factor and dopamine interactions in a heterogeneous ventral tegmental area: How can aversive experiences heighten cocaine self-administration? [D] . Holly, Elizabeth Nicole. 2015

机译：异质腹侧被盖区中促肾上腺皮质激素释放因子和多巴胺的相互作用：厌恶经历如何增强可卡因的自我管理？
6. Ventral Pallidum Is the Primary Target for Accumbens D1 Projections Driving Cocaine Seeking [O] . Thibaut R. Pardo-Garcia, Constanza Garcia-Keller, Tiffany Penaloza, 2019

机译：腹侧苍白质是促使可卡因寻求的D1投射的主要目标
7. Ventral Pallidum Is the Primary Target for Accumbens D1 Projections Driving Cocaine Seeking [O] . Thibaut R. Pardo-Garcia, Constanza Garcia-Keller, Tiffany Penaloza, 2019

机译：腹侧Pallidum是Accumbens D1投影的主要目标驱动可卡因寻求
8. Potentiated Reinstatement of Cocaine-Seeking Behavior Following Amphetamine Infusion into the Basolateral Amygdale [R] . Ledford, C. C. 2002

机译：安非他明输注到基底外侧amygdale后潜在的可卡因寻求行为的恢复

Ventral pallidum DRD3 potentiates a pallido-habenular circuit driving accumbal dopamine release and cocaine seeking

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