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首页> 外文期刊>Neuron >A substantia innominata-midbrain circuit controls a general aggressive response
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A substantia innominata-midbrain circuit controls a general aggressive response

机译：Innominata-midbrain电路控制一般的侵略性反应

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摘要

Although aggressive behaviors are universal and essential for survival, "uncontrollable"and abnormal aggressive behaviors in animals or humans may have severe adverse consequences or social costs. Neural circuits regulating specific forms of aggression under defined conditions have been described, but how brain circuits govern a general aggressive response remains unknown. Here, we found that posterior substantia innominata (pSI) neurons responded to several aggression-provoking cues with the graded activity of differential dynamics, predicting the aggressive state and the topography of aggression in mice. Activation of pSI neurons projecting to the periaqueductal gray (PAG) increased aggressive arousal and robustly initiated/promoted all the types of aggressive behavior examined in an activity-level-dependent manner. Inactivation of the pSI circuit largely blocked diverse aggressive behaviors but not mating. By encoding a general aggressive response, the pSI-PAG circuit universally drives multiple aggressive behaviors and may provide a potential target for alleviating human pathological aggression.
机译：None

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  • 来源
    《Neuron》 |2021年第9期|共23页
  • 作者

    Zhu Zhenggang; Ma Qingqing; Miao Lu; Yang Hongbin; Pan Lina; Li Kaiyuan; Zeng Ling-Hui; Zhang Xiaoxing; Wu Jintao; Hao Sijia; Lin Shen; Ma Xiulin; Mai Weihao; Feng Xiang; Hao Yizhe; Sun Li; Duan Shumin; Yu Yan-qin;

  • 作者单位

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Hangzhou 310058 Peoples R China;

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Hangzhou 310058 Peoples R China;

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Hangzhou 310058 Peoples R China;

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Hangzhou 310058 Peoples R China;

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Hangzhou 310058 Peoples R China;

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Hangzhou 310058 Peoples R China;

    Zhejiang Univ City Coll Sch Med Dept Pharmacol Hangzhou 310015 Zhejiang Peoples R China;

    Chinese Acad Sci Shanghai Inst Biol Sci Inst Neurosci Shanghai 200031 Peoples R China;

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Hangzhou 310058 Peoples R China;

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Hangzhou 310058 Peoples R China;

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Hangzhou 310058 Peoples R China;

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Hangzhou 310058 Peoples R China;

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Hangzhou 310058 Peoples R China;

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Hangzhou 310058 Peoples R China;

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Hangzhou 310058 Peoples R China;

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Hangzhou 310058 Peoples R China;

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Hangzhou 310058 Peoples R China;

    Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Neurobiol Hangzhou 310058 Peoples R China;

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  • 正文语种 eng
  • 中图分类 神经病学;
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