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首页> 外文期刊>Annals of behavioral medicine : >Physical activity and health outcomes among HIV-infected men who have sex with men: A longitudinal mediational analysis
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Physical activity and health outcomes among HIV-infected men who have sex with men: A longitudinal mediational analysis

机译：与男性发生性关系的艾滋病毒感染男性的体育锻炼和健康结局：纵向中介分析

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Background: Low physical activity is associated with depression, which may, in turn, negatively impact antiretroviral therapy (ART) adherence among HIV-infected individuals; however, prior studies have not investigated the relationships between physical inactivity and ART non-adherence. Purpose: The purpose of this study was to examine the association of physical inactivity, depression, ART non-adherence, and viral load in HIV-infected men who have sex with men. Methods: The sample (N = 860) was from a large, multicenter cohort of HIV-infected patients engaged in clinical care. Results: Across time, depression mediated the relationship between physical inactivity and ART non-adherence (γ = 0.075) and the relationship between physical inactivity and viral load (γ = 0.05). ART non-adherence mediated the relationship between depression and viral load (γ = 0.002) and the relationship between physical inactivity and viral load (γ = 0.009). Conclusions: Low levels of physical activity predicted increased depression and poor ART adherence over time, which subsequently predicted higher viral load.
机译：背景：体力活动低下与抑郁症有关，而抑郁症又可能对感染HIV的个体的抗逆转录病毒疗法（ART）依从性产生负面影响;然而，先前的研究尚未研究缺乏运动与抗逆转录病毒疗法之间的关系。目的：本研究的目的是检查与男性发生性行为的艾滋病毒感染男性的身体不活动，抑郁，抗逆转录病毒治疗不依从性和病毒载量的相关性。方法：样本（N = 860）来自一个大型的多中心HIV感染患者临床研究队列。结果：随着时间的推移，抑郁症介导了身体不活动与抗逆转录病毒药物非粘附性之间的关系（γ= 0.075）以及身体不活动与病毒载量之间的关系（γ= 0.05）。非坚持抗逆转录病毒介导抑郁与病毒载量之间的关系（γ= 0.002）以及身体不活动与病毒载量之间的关系（γ= 0.009）。结论：低水平的体育活动可预测抑郁症的增加和抗逆转录病毒依从性随时间的推移而增加，随后可预测病毒载量更高。

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