Repetitive DNA loci and their modulation by the non-canonical nucleic acid structures R-loops and G-quadruplexes

Hall Amanda C.; Ostrowski Lauren A.; Pietrobon Violena; Mekhail Karim

首页> 外文期刊>Nucleus >Repetitive DNA loci and their modulation by the non-canonical nucleic acid structures R-loops and G-quadruplexes

【24h】

Repetitive DNA loci and their modulation by the non-canonical nucleic acid structures R-loops and G-quadruplexes

机译：重复DNA基因座及其通过非规范核酸结构R-环和G-四翻转的调节

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Cells have evolved intricate mechanisms to maintain genome stability despite allowing mutational changes to drive evolutionary adaptation. Repetitive DNA sequences, which represent the bulk of most genomes, are a major threat to genome stability often driving chromosome rearrangements and disease. The major source of repetitive DNA sequences and thus the most vulnerable constituents of the genome are the rDNA (rDNA) repeats, telomeres, and transposable elements. Maintaining the stability of these loci is critical to overall cellular fitness and lifespan. Therefore, cells have evolved mechanisms to regulate rDNA copy number, telomere length and transposon activity, as well as DNA repair at these loci. In addition, non-canonical structure-forming DNA motifs can also modulate the function of these repetitive DNA loci by impacting their transcription, replication, and stability. Here, we discuss key mechanisms that maintain rDNA repeats, telomeres, and transposons in yeast and human before highlighting emerging roles for non-canonical DNA structures at these repetitive loci.

机译：None

著录项

来源
《Nucleus》 |2017年第2期|共20页
作者
Hall Amanda C.; Ostrowski Lauren A.; Pietrobon Violena; Mekhail Karim;
展开▼
作者单位

Univ Toronto Dept Lab Med &

Pathobiol Fac Med Toronto ON Canada;

Univ Toronto Dept Lab Med &

Pathobiol Fac Med Toronto ON Canada;

Univ Toronto Dept Lab Med &

Pathobiol Fac Med Toronto ON Canada;

Univ Toronto Dept Lab Med &

Pathobiol Fac Med Toronto ON Canada;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
genome stability; rDNA (rDNA); repetitive DNA; retrotransposons; telomeres;

机译：基因组稳定性;RDNA（rDNA）;重复DNA;回复转移;端粒;

相似文献

外文文献
中文文献
专利

1. Characterization of root-associated bacterial community structures in soybean and corn using locked nucleic acid (LNA) oligonucleotide-PCR clamping and 454 pyrosequencing [J] . YU Zhen-hua, YU Jiang, Makoto Ikenaga, 农业科学学报（英文版） . 2016,第008期
2. Characterization of root-associated bacterial community structures in soybean and corn using locked nucleic acid（LNA） oligonucleotide-PCR clamping and 454 pyrosequencing [J] . YU Zhen-hua, YU Jiang12, Makoto Ikenaga, 农业科学学报：英文版 . 2016,第008期
3. Synthesis of Thermostable Azo-type Photoswitches towards Photoreaulatina Nucleic Acid Structures [J] . WANG Qi, GAO Shuang, ZHOU Kai, 中国化学（英文版） . 2009,第008期
4. Monitoring lamivudine therapy in HBV-infected patients by the quantity and structures of circulating viral nucleic acids [J] . ZHANG Wei(张伟), Hans Jorg Hacker, Maria Mildenberger, 中国人民解放军军医大学学报（英文版） . 2003,第003期
5. Repetitive DNA loci and their modulation by the non-canonical nucleic acid structures R-loops and G-quadruplexes [J] . Amanda C. Hall, Lauren A. Ostrowski, Violena Pietrobon, Nucleus . 2017,第2期

机译：重复DNA基因座及其通过非规范核酸结构R环和G四联体的调控
6. Repetitive DNA loci and their modulation by the non-canonical nucleic acid structures R-loops and G-quadruplexes [J] . Hall Amanda C., Ostrowski Lauren A., Pietrobon Violena, Nucleus . 2017,第2期

机译：重复DNA基因座及其通过非规范核酸结构R-环和G-四翻转的调节
7. Toward predictive R-loop computational biology: genome-scale prediction of R-loops reveals their association with complex promoter structures, G-quadruplexes and transcriptionally active enhancers [J] . Vladimir A Kuznetsov, Vladyslav Bondarenko, Thidathip Wongsurawat, Nucleic acids research . 2018,第15期

机译：迈向预测性R环计算生物学：R环的基因组规模预测揭示了它们与复杂的启动子结构，G-四链体和转录活性增强子的关联
8. Scanning tunneling microscopic imaging of electrostatically immobilized nucleic acids: the influence of self-assembled monolayer structure on the binding of plasmid DNA to gold surfaces [C] . Lawrence A. Bottomley, Georgia Institute of Technology, Atlanta, Advances in DNA Sequencing Technology . 1993

机译：静电固定核酸的扫描隧道显微镜成像：自组装单层结构对质粒DNA与金表面结合的影响
9. Thymine/uracil recognition in non-canonical nucleic acid structures by zinc macrocycle complexes [D] . del Mundo, Imee Marie A. 2011

机译：锌大环复合物在非规范核酸结构中对胸腺嘧啶/尿嘧啶的识别
10. Repetitive DNA loci and their modulation by the non-canonical nucleic acid structures R-loops and G-quadruplexes [O] . Amanda C. Hall, Lauren A. Ostrowski, Violena Pietrobon, 2018

机译：重复DNA基因座及其通过非规范核酸结构R环和G四联体的调控
11. NAMOT2—a redesigned nucleic acid modeling tool: construction of non-canonical DNA structures [O] . Eugene S. Carter, Chang-Shung Tung 1996

机译：Namot2-A重新设计的核酸建模工具：非典型DNA结构的构建
12. Studies on the Structure of Nucleic Acids. I. Interaction of Rosaniline with Desoxypentoss Nucleic Acid. [R] . Cavalieri, L. F., Angelos, A. 1950

机译：研究核酸的结构。 I. Rosaniline的互动与Desoxypentoss核酸。

Repetitive DNA loci and their modulation by the non-canonical nucleic acid structures R-loops and G-quadruplexes

摘要

著录项

相似文献

相关主题

期刊订阅