Adequate tetanus but poor diphtheria and pertussis response to a Tdap booster in adolescents with juvenile systemic lupus erythematosus

Octávio AB Peracchi; Aline Alencar MF Nicácio; Juliana Yamada; Claudio Arnaldo Len; Maria Isabel de Moraes-Pinto; Maria Teresa Terreri

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Adequate tetanus but poor diphtheria and pertussis response to a Tdap booster in adolescents with juvenile systemic lupus erythematosus

机译：足够的破伤风，但白喉贫困和百日咳对少年全身狼疮红斑狼疮的青少年的TDAP增强剂的反应

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Background Reports on vaccine responses in immunocompromised patients, such as juvenile systemic lupus erythematosus (jSLE), have shown highly variable results. Objective To compare the immune response and safety after a Tdap booster in 26 jSLE patients and 26 matched healthy adolescents. Methodology: Adverse events and disease activity were evaluated. Lymphocyte immunophenotyping was performed by flow cytometry. Tetanus, diphtheria and pertussis toxin antibodies were assessed by ELISA; whole blood was stimulated with whole cell pertussis and supernatants were assessed for cytokines by xMAP. Results Both groups showed a similar frequency of adverse events. There was no evidence of disease reactivation after Tdap booster in the jSLE cohort. Both groups showed a significant increase in antibody titers for all three antigens on D14 and D28 (p?

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来源
《Lupus》 |2021年第2期|共8页
作者
Octávio AB Peracchi; Aline Alencar MF Nicácio; Juliana Yamada; Claudio Arnaldo Len; Maria Isabel de Moraes-Pinto; Maria Teresa Terreri;
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作者单位

Unit of Pediatric Rheumatology Department of Pediatrics Universidade Federal de S?o Paulo;

Unit of Pediatric Rheumatology Department of Pediatrics Universidade Federal de S?o Paulo;

Research Laboratory Division of Pediatric Infectious Diseases Department of Pediatrics;

Unit of Pediatric Rheumatology Department of Pediatrics Universidade Federal de S?o Paulo;

Research Laboratory Division of Pediatric Infectious Diseases Department of Pediatrics;

Unit of Pediatric Rheumatology Department of Pediatrics Universidade Federal de S?o Paulo;

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原文格式 PDF
正文语种 eng
中图分类免疫性疾病;
关键词
Juvenile systemic lupus erythematosus; vaccine; vaccine against diphtheria; tetanus and acellular pertussis; Tdap; immunogenicity; adolescents;

机译：少年全身狼疮红斑狼疮;疫苗;对白喉疫苗;破伤风和无细胞植物;TDAP;免疫原性;青少年;

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2. Chinese Systemic Lupus Erythematosus Treatment and Research Group Registry IX: Clinical Features and Survival of Childhood?Onset Systemic Lupus Erythematosus in China [J] . Chan‑Yuan Wu, Meng‑Tao Li, Yan Zhao, 中华医学杂志（英文版） . 2017,第011期
3. Spotlight on Tdap vaccine (Covaxis(R)) as a single-booster immunization for the prevention of tetanus, diphtheria, and pertussis: in children (aged >/=4 years), adolescents, and adults. [J] . Scott LJ Pediatric drugs . 2011,第2期

机译：预防性破伤风，白喉和百日咳的单次加强免疫Tdap疫苗（Covaxis®）受到关注：儿童（> / = 4岁），青少年和成人。
4. Tdap5 vaccine (Covaxis): a review of its use as a single-booster immunization for the prevention of tetanus, diphtheria, and pertussis in children (aged 4 years), adolescents, and adults. [J] . Scott LJ BioDrugs: Clinical immunotherapeutics, biopharmaceuticals, and gene therapy . 2010,第6期

机译：Tdap5疫苗（Covaxis）：综述其在儿童（4岁以下），青少年和成人中作为单次加强免疫预防破伤风，白喉和百日咳的用途。
5. Tolerability and antibody response in adolescents and adults revaccinated with tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine adsorbed (Tdap) 4–5 years after a previous dose [J] . Scott A. Halperin, Shelly McNeil, Joanne Langley, Vaccine . 2011,第46期

机译：接种破伤风类毒素，减少白喉类毒素和脱细胞百日咳疫苗（Tdap）的青少年和成年人接种前4-5年后的耐受性和抗体反应
6. Biomarker Status of Proteins in Circulating Immune Complexes Isolated from Dermatomyositis, Systemic Lupus Erythematosus and Juvenile Idiopathic Arthritis Plasma [C] . Leticia Cano American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：循环免疫复合物中蛋白质的生物标志物状态从皮肤病，全身性狼疮红斑和幼年特发性关节炎等离子体中分离出来的免疫复合物
7. Healthcare Provider and Support Staff Education to Increase Tetanus, Diphtheria, and Acellular Pertussis Immunizations Among Pregnant Women in a Mid-Western Ob/Gyn Clinic [D] . Henderson, Krissi. 2020

机译：医疗保健提供者和支持人员教育增加了患有中西部ob / gyn诊所的孕妇中的破伤风，白喉和患有细胞植物免疫
8. How long can we expect pertussis protection to last after the adolescent booster dose of tetanus-diphtheria-pertussis (Tdap) vaccines? [O] . Nawaf Al Dajani, David Scheifele 2007

机译：在青少年加强剂量的破伤风-白喉-百日咳（Tdap）疫苗接种后我们预期百日咳保护将持续多久？
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机译：在青少年加强剂量的破伤风-白喉-百日咳（Tdap）疫苗接种后，我们预期百日咳保护将持续多久？
10. Preventing Tetanus, Diphtheria, and Pertussis Among Adolescents: Use of Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccines. Recommendations of the Advisory Committee on Immunization Practices (ACIP). Morbidity and Mortality Wee [R] . 2006

机译：在青少年中预防破伤风，白喉和百日咳：使用破伤风类毒素，减少白喉类毒素和无细胞汗液疫苗。免疫接种实践咨询委员会（aCIp）的建议。发病率

Adequate tetanus but poor diphtheria and pertussis response to a Tdap booster in adolescents with juvenile systemic lupus erythematosus

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