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首页> 外文期刊>Annals of neurology >Autoimmune encephalopathy: the spectrum widens.
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Autoimmune encephalopathy: the spectrum widens.

机译：自身免疫性脑病：范围扩大。

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In 1997, Nokura and colleagues1 described a 19-year-old woman who developed memory loss, psychosis, seizures, central hypoventilation, and coma. An ovarian ter-atoma was discovered and removed, after which she made a partial recovery. Antineuronal antibodies were searched for, but not found. Other case reports appeared in the next few years, but no antibody was identified; for example, in 1999 Taylor and colleagues2 reported on a 24-year-old woman who presented with a 3-week history of memory loss, behavioral changes, auditory hallucinations, and hypersomnolence. She developed central respiratory failure and a flaccid paraplegia. An MRI initially showed no abnormalities, but a subsequent study, after the respiratory failure, revealed increased T2 signal in the medulla and spinal cord. There was a mild cere-brospinal fluid (CSF) pleocytosis. A pelvic mass that proved to be an ovarian teratoma was found and removed. The surgery along with immunosuppression by high-dose corticosteroids and intravenous immunoglob-ulin (IVIG) led to a full recovery.
机译：在1997年，Nokura及其同事1描述了一名19岁的妇女，她患有记忆力减退，精神病，癫痫发作，中枢通气不足和昏迷。发现并切除了卵巢畸胎瘤，之后她得到了部分康复。搜索但未找到抗神经元抗体。在接下来的几年中出现了其他病例报告，但是没有发现抗体。例如，在1999年，Taylor及其同事2报道了一位24岁的女性，该女性有3周的记忆力减退，行为改变，听觉幻觉和嗜睡感。她发展为中枢性呼吸衰竭和松弛性截瘫。 MRI最初未显示异常，但随后的研究在呼吸衰竭后发现延髓和脊髓中的T2信号增加。轻度脑脊液（CSF）胞吞。发现并去除了证实为卵巢畸胎瘤的骨盆肿块。手术以及大剂量皮质类固醇和静脉内免疫球蛋白（IVIG）的免疫抑制导致完全康复。

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