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首页> 外文期刊>Reproductive toxicology >Effects of isoliquiritigenin on ovarian antral follicle growth and steroidogenesis
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Effects of isoliquiritigenin on ovarian antral follicle growth and steroidogenesis

机译：Isoliquiritigenin对卵巢胃窦卵泡生长和甾体系的影响

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Isoliquiritigenin is a botanical estrogen used as a dietary supplement. Previous studies show that other botanical estrogens affect ovarian estradiol synthesis, but isoliquiritigenin's effects on the ovary are unknown. Thus, this study tested the hypothesis that isoliquiritigenin inhibits ovarian antral follicle growth and steroidogenesis. Antral follicles from CD-1 mice were cultured with vehicle control (dimethyl sulfoxide; DMSO) or isoliquiritigenin (0.6 mu M, 6 p,M, 36 mu M, and 100 mu M) for 48-96 h. During culture, follicle diameters were measured daily to assess follicle growth. After culture, media were collected for hormone assays and follicles were collected for gene expression analysis of steroidogenic enzymes. Isoliquiritigenin inhibited antral follicle growth and altered estradiol, testosterone, and progesterone levels. Additionally, isoliquiritigenin altered the mRNA levels of cytochrome P450 steroid 17-alpha-hydroxylase 1, aromatase, 17 beta-hydroxysteroid dehydrogenase 1, and steroidogenic acute regulatory protein. These data indicate that exposure to isoliquiritigenin inhibits growth and disrupts steroid production in antral follicles. (C) 2016 Elsevier Inc. All rights reserved.
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