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首页> 外文期刊>Annals of Nutrition & Metabolism >Effect of supplementation with docosahexaenoic acid ethyl ester and sn-2 docosahexaenyl monoacylglyceride on plasma and erythrocyte fatty acids in rats
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Effect of supplementation with docosahexaenoic acid ethyl ester and sn-2 docosahexaenyl monoacylglyceride on plasma and erythrocyte fatty acids in rats

机译：补充二十二碳六烯酸乙酯和sn-2二十二碳六烯基单酰基甘油酯对大鼠血浆和红细胞脂肪酸的影响

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BACKGROUND/AIMS: Docosahexaenoic acid (C22:6, DHA) is an omega-3 fatty acid required for the normal development of the mammalian nervous and visual system. DHA is provided by the mother during pregnancy and lactating period. Mother's DHA supplementation during pregnancy, and even before pregnancy, has been suggested. DHA can be provided by marine oils, egg's yolk phospholipids, single cell algae oils, the pure fatty acid, or by the ethyl ester derivative (DHA-EE). Another way to provide DHA can be by sn-2 docosahexaenyl monoacylglyceride (DHA-MG), obtained by the treatment of fish oil with stereospecific lipases. sn-2 Fatty acid monoacylglycerides can be more easily absorbed at the intestine than other fatty acid derivatives. METHODS: Female rats fed with a synthetic, which provided essentially no DHA, received a 40-day supplementation of either DHA-EE or DHA-MG. Plasma and erythrocyte fatty acid composition were assessed by gas chromatography at day 0 and 40 of supplementation. RESULTS: DHA-EE increased plasma and erythrocyte DHA by 15 and 11.9%, respectively, with no modification of arachidonic acid (AA) content. DHA-MG supplementation increased plasma and erythrocyte DHA by 24 and 23.8%, respectively, but reduced AA by 5.5 and 3%, respectively. CONCLUSIONS: We conclude that in the rat, DHA-MG supplementation allows a higher plasma and erythrocyte DHA content than DHA-EE with minor modification of AA content.
机译：背景/目的：二十二碳六烯酸（C22：6，DHA）是哺乳动物神经和视觉系统正常发育所必需的omega-3脂肪酸。母亲在怀孕和哺乳期间提供DHA。建议在怀孕期间甚至在怀孕前补​​充母亲的DHA。 DHA可以由船用油，蛋黄磷脂，单细胞藻类油，纯脂肪酸或乙酯衍生物（DHA-EE）提供。提供DHA的另一种方法可以是sn-2二十二碳六烯基单酰基甘油酯（DHA-MG），它是通过用立体特异性脂肪酶处理鱼油而获得的。 sn-2脂肪酸单酰基甘油酯比其他脂肪酸衍生物更容易在肠道吸收。方法：雌性大鼠饲喂基本不提供DHA的合成饲料，可以补充40天的DHA-EE或DHA-MG。在补充的第0天和第40天，通过气相色谱法评估血浆和红细胞脂肪酸组成。结果：DHA-EE使血浆和红细胞DHA分别增加15％和11.9％，而花生四烯酸（AA）含量未发生变化。补充DHA-MG可使血浆DHA和红细胞DHA分别增加24和23.8％，但使AA减少5.5和3％。结论：我们得出的结论是，与DHA-EE相比，补充DHA-MG可以使血浆和红细胞的DHA含量更高，而对AA含量的修饰很小。

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