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首页> 外文期刊>Analytical methods >A miniaturized chemiluminescence detection system for a microfluidic paper-based analytical device and its application to the determination of chromium(III)
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A miniaturized chemiluminescence detection system for a microfluidic paper-based analytical device and its application to the determination of chromium(III)

机译：一种基于微流纸的分析仪器的微型化学发光检测系统及其在铬（III）测定中的应用

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摘要

A miniaturized detection system for chemiluminescence that is generated on a microfluidic paper-based analytical device (mu PAD) was developed using optical fibers and was applied to the determination of Cr(III). The mPAD was fabricated by wax printing and consisted of 6 separate channels in a parallel alignment. Each channel was composed of an injection zone for a reagent solution, a reaction zone, and a waste zone. The mu PAD was placed on a plastic holder equipped with 6 optical fibers to collect chemiluminescence (CL). The other ends of the optical fibers were bundled and introduced into a small photomultiplier tube module to obtain the CL signals. The CL reaction was based on luminol oxidation by hydrogen peroxide in the presence of Cr(III), which catalyzed the reaction in an alkaline medium. The reaction conditions, including the use of an enhancer and a masking agent, were optimized to obtain high sensitivity and selectivity. Under the optimal conditions, a linear range was obtained at 0.05 to 1.00 ppm with a detection limit of 0.02 ppm. The analysis time was less than 1 min per one mu PAD in order to obtain 6 measurements of differing concentrations with a precision of < 6.5%. This method was successfully applied to the determination of Cr(III) spiked into natural water samples at the sub-ppm range.
机译：使用光纤开发了在基于微流体纸的分析设​​备（mu PAD）上生成的化学发光微型检测系统，并将其应用于Cr（III）的测定。 mPAD通过蜡印制成，由6个平行排列的独立通道组成。每个通道由试剂溶液的注入区，反应区和废液区组成。将mu PAD放在配有6条光纤的塑料支架上，以收集化学发光（CL）。光纤的另一端被捆扎并引入一个小的光电倍增管模块中以获得CL信号。 CL反应基于在Cr（III）存在下过氧化氢的鲁米诺氧化反应，该反应在碱性介质中催化该反应。优化反应条件，包括使用增强剂和掩蔽剂，以获得高灵敏度和选择性。在最佳条件下，线性范围为0.05至1.00 ppm，检出限为0.02 ppm。每1亩PAD的分析时间少于1分钟，以便获得6种浓度<6.5％的不同浓度的测量值。该方法成功地用于测定亚ppm级范围内加到天然水样品中的Cr（III）。

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