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首页> 外文期刊>Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer >Resistance training as supportive measure in advanced cancer patients undergoing TKI therapy—a controlled feasibility trial
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Resistance training as supportive measure in advanced cancer patients undergoing TKI therapy—a controlled feasibility trial

机译：抗性培训作为高级癌症患者的支持措施，接受TKI治疗 - 一种受控可行性试验

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Abstract Purpose While there is growing evidence for positive effects of progressive resistance training in curatively treated cancer patients, data on advanced cancer patients are scarce. This pilot study aimed at investigating for the first time feasibility and effects of progressive resistance training in advanced cancer patients undergoing tyrosine kinase inhibitor (TKI) therapy. Methods Patients starting a TKI-based anti-tumor therapy were assigned to a resistance training group (RT, 12?weeks of progressive machine-based resistance training 2×/week) or a control group (CON, treatment as usual) until 10 patients had finished in each group (RT 80% males, 90% renal cell carcinoma, 65?±?11?years, CON 80% males, 70% renal cell carcinoma, 61?±?6?years). Primary endpoint was feasibility. Furthermore, fatigue (MFI), quality of life (QoL, EORTC QLQC30), and muscle strength were assessed. Testing occurred at baseline and after 12?weeks. Results Training was feasible in 9 out of 10 participants and no serious adverse events occurred. It had beneficial effects on muscle strength (maximum voluntary isometric contraction of the quadriceps: RT +11?±?9?Nm, CON ?13?±?25?Nm, p ?=?0.005), but not on fatigue (general fatigue score RT +0.3?±?4.1, CON -1.5?±?3.0, p ?=?0.223) or QoL (global QoL score RT ?5.6?±?16.1, CON ?2.0?±?18.2, p ?=?0.617). Conclusions Progressive machine-based resistance training appears feasible in the majority of advanced cancer patients undergoing TKI therapy. However, its positive effects on muscle strength do not seem to be associated with positive effects on fatigue or quality of life. Future studies should therefore compare whether home-based training is more beneficial for patient-reported outcomes. Trial registration NCT01645150
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