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Recombinant subunit vaccines for soil-transmitted helminths

机译：用于土壤传播蠕虫的重组亚基疫苗

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Soil-transmitted helminths (STHs) collectively infect one fourth of all human beings, and themajority of livestock in the developing world. These gastrointestinal nematodes are the most important parasites on earth with regard to their prevalence in humans and livestock. Current anthelmintic drugs are losing their efficacies due to increasing drug resistance, particularly in STHs of livestock and drug treatment is often followed by rapid reinfection due to failure of the immune system to develop a protective response. Vaccines against STHs offer what drugs cannot accomplish alone. Because such vaccines would have to be produced on such a large scale, and be cost effective, recombinant subunit vaccines that include aminimumnumber of proteins produced in relatively simple and inexpensive expression systems are required. Here, we summarize all of the previous studies pertaining to recombinant subunit vaccines for STHs of humans and livestock with the goal of both informing the public of just how critical these parasites are, and to help guide future developments. Wealso discuss several key areas of vaccine development, which we believe to be critical for developing more potent recombinant subunit vaccines with broad-spectrum protection.
机译：土壤传播的蠕虫（STH）共同感染着发展中国家四分之一的人类和大部分牲畜。这些胃肠道线虫是地球上最重要的寄生虫，在人类和家畜中普遍存在。目前的驱虫药物由于耐药性的增加而失去了效力，尤其是在牲畜的STH中，药物治疗后，由于免疫系统无法产生保护性反应，往往会迅速再次感染。抗STH的疫苗提供了药物无法单独完成的功能。由于这类疫苗必须大规模生产，而且具有成本效益，因此需要包含在相对简单且廉价的表达系统中产生的大量蛋白质的重组亚单位疫苗。在这里，我们总结了之前所有关于人类和家畜STH重组亚单位疫苗的研究，目的是让公众了解这些寄生虫的重要性，并帮助指导未来的发展。我们还将讨论疫苗开发的几个关键领域，我们认为这些领域对于开发具有广谱保护的更有效的重组亚单位疫苗至关重要。

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