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首页> 外文期刊>Parasitology >Diagnostic comparison of stool exam and point-of-care circulating cathodic antigen (POC-CCA) test for schistosomiasis mansoni diagnosis in a high endemicity area in northeastern Brazil
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Diagnostic comparison of stool exam and point-of-care circulating cathodic antigen (POC-CCA) test for schistosomiasis mansoni diagnosis in a high endemicity area in northeastern Brazil

机译：诊断比较巴西高流行区血吸虫病曼逊诊断血吸虫病麦森诊断的诊断比较

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摘要

This study aimed to evaluate the performance of the point-of-care circulating cathodic antigen (POC-CCA) test in a highly endemic area in Brazil, comparing it to the Kato-Katz (KK) technique for sensitivity, specificity and the intensity of the reaction of the test in relation to the parasitic load. The community in Sergipe, Brazil, participated in the study, providing three stool samples, one of urine (POC-CCA) and fingers tick blood sample was tested by enzyme-linked immunosorbent assay (ELISA). Sensitivity, specificity, positive predictive value, negative predictive value, accuracy, kappa coefficient and Spearman's correlation were calculated for the POC-CCA test using the KK as the reference. The prevalence of schistosomiasis by KK testing was 48.82%; POC-CCA ((+) 66.14%; POC-CCA (f-) 45.24%. ELISA results showed 100% agreement in individuals with high and moderate eggs per gram (EPG). POC-CCA presented good diagnostic performance in individuals with medium and high EPG, but there were a high number of false negatives in individuals with low intensity infections. As observed, POC-CCA-filter test improves accuracy and sensitivity compared to a conventional test.
机译：本研究旨在评估护理点循环阴极抗原（POC-CCA）试验在巴西一个高度流行地区的性能，并将其与卡托-卡茨（KK）技术在灵敏度、特异性和与寄生虫负荷相关的试验反应强度方面进行比较。巴西塞尔吉佩的社区参与了这项研究，提供了三份粪便样本，其中一份尿液（POC-CCA）和手指蜱血样本通过酶联免疫吸附试验（ELISA）进行了检测。以KK为参考，计算POC-CCA试验的敏感性、特异性、阳性预测值、阴性预测值、准确性、kappa系数和Spearman相关性。KK检测血吸虫病患病率为48.82%；POC-CCA（+）66.14%；POC-CCA（f-）45.24%。ELISA结果显示，在每克高和中等卵子（EPG）的个体中，一致性为100%。POC-CCA在中等和高EPG个体中表现出良好的诊断性能，但在低强度感染个体中有大量假阴性。据观察，与传统测试相比，POC CCA过滤器测试提高了准确性和灵敏度。

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  • 来源
    《Parasitology》 |2021年第4期|共7页
  • 作者

    Danielle de Freitas Bezerra;

  • 作者单位

    Post-Graduate Program in Pathology School of Medicine Federal University of Ceara Fortaleza;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 寄生虫病;
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