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Effectiveness of doxycycline for the treatment of zoonotic cutaneous leishmaniasis in vivo

机译：锰酸盐素治疗体内动物园皮肤无山脉的有效性

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摘要

There are available data on in vivo studies of monotherapy of zoonotic cutaneous leishmaniasis with some antibacterial drugs (doxycycline) and their comparison with meglumine anti-moniate (glucantime). We used golden Syrian hamsters as a laboratory model. Experimental groups were formed, each of which was treated with one of the tested drugs. Infection of animals was carried out with Leishmania major promastigotes. We selected highly virulent strains of L. major culture isolated from human ulcers or rodents. Meglumine antimoniate monotherapy and doxycycline monotherapy are quite effective and do not differ by the 30th day of their use in such indicators as the average degree of local damage and the average number of Leishmania in the lesions. The main differences were recorded in terms of average body weight gain and average clinical recovery in favour of doxycycline. Leishmania in the lesion on the 60th day were completely absent in treatment with doxycycline. The experiment proved the effectiveness of doxycycline monotherapy: Leishmania in the lesions were absolutely absent by the end of the treatment.
机译：有可用的数据表明，使用一些抗菌药物（强力霉素）单一治疗人畜共患病皮肤利什曼病，并与葡胺抗monitate（葡聚糖时间）进行比较。我们用金色叙利亚仓鼠作为实验室模型。形成实验组，每个实验组用一种受试药物治疗。动物感染主要利什曼原虫前鞭毛体。我们选择了从人类溃疡或啮齿类动物中分离的主要L.菌的高毒力菌株。抗肌张力葡胺单药疗法和强力霉素单药疗法相当有效，在使用第30天时，局部损伤的平均程度和病变中利什曼原虫的平均数量等指标没有差异。记录的主要差异是在平均体重增加和平均临床恢复方面，多西环素是有利的。在使用强力霉素治疗的第60天，病变中完全没有利什曼原虫。实验证明了强力霉素单药治疗的有效性：治疗结束时，病变中完全没有利什曼原虫。

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