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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Metabolite Levels in Paediatric Brain Tumours Correlate with Histological Features
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Metabolite Levels in Paediatric Brain Tumours Correlate with Histological Features

机译：儿科脑肿瘤的代谢物水平与组织学特征相关联

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Aims: Metabolite levels can be measured non-invasively using in vivo H-1 magnetic resonance spectroscopy (MRS). These tumour metabolite profiles are highly characteristic for tumour type in childhood brain tumours; however, the relationship between metabolite values and conventional histopathological characteristics has not yet been fully established. This study systematically tests the relationship between metabolite levels detected by MRS and specific histological features in a range of paediatric brain tumours. Methods: Single-voxel MRS was performed routinely in children with brain tumours along with the clinical imaging prior to treatment. Metabolites were quantified using LC-Model. Histological features were assessed semi-quantitatively for 27 children on H&E and immunostained slides, blind to the metabolite values. Statistical analysis included 2-tailed independent-samples t tests and 2-tailed Spearman rank correlation tests. Results: Ki67, cellular atypia, and mitosis correlated positively with choline metabolites, and phosphocholine in particular. Apoptosis and necrosis were both associated with lipid levels, with the relationship dependent on the use of long or short echo time MRS acquisitions. Neuronal components correlated negatively and glial components positively with N-acetyl-aspartate. Glial components correlated positively with myoinositol. Conclusion: Metabolite levels in children's brain tumours measured by MRS are closely associated with key histological features routinely assessed by histopathologists in the diagnostic process. This further elucidates our understanding of this important non-invasive diagnostic tool and strengthens our understanding of the relationship between metabolites and histological features. (C) 2018 S. Karger AG, Basel
机译：目的：利用体内H-1磁共振波谱（MRS）可以无创地测量代谢物水平。这些肿瘤代谢物图谱对于儿童期脑瘤的肿瘤类型具有高度的特征性；然而，代谢物值与常规组织病理学特征之间的关系尚未完全确定。本研究系统地测试了MRS检测到的代谢物水平与一系列儿童脑肿瘤的特定组织学特征之间的关系。方法：对患有脑肿瘤的儿童常规进行单体素磁共振成像，并在治疗前进行临床成像。代谢物用LC模型定量。在H&E和免疫染色玻片上对27名儿童的组织学特征进行半定量评估，对代谢物值视而不见。统计分析包括双尾独立样本t检验和双尾Spearman秩相关检验。结果：Ki67、细胞异型性和有丝分裂与胆碱代谢产物，尤其是磷酸胆碱呈正相关。凋亡和坏死都与脂质水平有关，两者之间的关系取决于长或短回声时间MRS采集的使用。神经元成分与N-乙酰天冬氨酸呈负相关，胶质成分与N-乙酰天冬氨酸呈正相关。胶质成分与肌醇呈正相关。结论：通过MRS测量的儿童脑肿瘤代谢物水平与组织病理学家在诊断过程中常规评估的关键组织学特征密切相关。这进一步阐明了我们对这一重要的非侵入性诊断工具的理解，并加强了我们对代谢物和组织学特征之间关系的理解。（C） 2018年巴塞尔S.卡格股份公司

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