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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Metabolite Levels in Paediatric Brain Tumours Correlate with Histological Features
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Metabolite Levels in Paediatric Brain Tumours Correlate with Histological Features

机译：儿科脑肿瘤的代谢物水平与组织学特征相关联

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Aims: Metabolite levels can be measured non-invasively using in vivo H-1 magnetic resonance spectroscopy (MRS). These tumour metabolite profiles are highly characteristic for tumour type in childhood brain tumours; however, the relationship between metabolite values and conventional histopathological characteristics has not yet been fully established. This study systematically tests the relationship between metabolite levels detected by MRS and specific histological features in a range of paediatric brain tumours. Methods: Single-voxel MRS was performed routinely in children with brain tumours along with the clinical imaging prior to treatment. Metabolites were quantified using LC-Model. Histological features were assessed semi-quantitatively for 27 children on H&E and immunostained slides, blind to the metabolite values. Statistical analysis included 2-tailed independent-samples t tests and 2-tailed Spearman rank correlation tests. Results: Ki67, cellular atypia, and mitosis correlated positively with choline metabolites, and phosphocholine in particular. Apoptosis and necrosis were both associated with lipid levels, with the relationship dependent on the use of long or short echo time MRS acquisitions. Neuronal components correlated negatively and glial components positively with N-acetyl-aspartate. Glial components correlated positively with myoinositol. Conclusion: Metabolite levels in children's brain tumours measured by MRS are closely associated with key histological features routinely assessed by histopathologists in the diagnostic process. This further elucidates our understanding of this important non-invasive diagnostic tool and strengthens our understanding of the relationship between metabolites and histological features. (C) 2018 S. Karger AG, Basel
机译：目的：代谢物水平可以在体内H-1磁共振光谱（MRS）中无侵入性地测量。这些肿瘤代谢物谱对儿童脑肿瘤的肿瘤类型具有高度特征性;然而，代谢物值与常规组织病理学特征之间的关系尚未完全建立。本研究系统地测试了一系列儿科脑肿瘤中MRS和特定组织学特征检测到的代谢物水平之间的关系。方法：在治疗前，单voxel MRS常规于脑肿瘤的儿童进行，以及临床成像。使用LC模型量化代谢物。对H＆E和免疫染色的27名儿童进行半定量评估组织学特征，对代谢物值视而不见。统计分析包括2次尾独立样品T检验和2尾的Sp​​earman等级相关测试。结果：Ki67，细胞缺剂和有丝分裂与胆碱代谢物相关，特别是磷光啉。细胞凋亡和坏死均与脂质水平有关，与长期或短期时间MRS收购的使用关系。神经元成分用N-乙酰基 - 天冬氨酸呈正相关和胶质组分相关。胶质组分与肌肌醇正相关。结论：MRS测量的儿童脑肿瘤的代谢物水平与诊断过程中组织病理学家常规评估的关键组织学特征密切相关。这进一步阐明了我们对这一重要的非侵入性诊断工具的理解，并加强了我们对代谢物和组织学特征之间关系的理解。 （c）2018年S. Karger AG，巴塞尔

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